Difference between revisions of "Team:Peking"

 
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<h2><center>Welcome to Peking iGEM 2015!</center></h2>
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<h4> <center>Project Description</center> </h4>
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<p>Tuberculosis (TB), caused by <i>Mycobacterium tuberculosis</i>, remains one of the world’s most serious public health problems. Although tuberculosis is curable and the treatment success rate is high, it is still the second most common cause of death from infectious disease (after HIV). Most of the deaths occur in developing countries that are lack of effective identification of those in need of therapy. In 2014 there were 5 million active cases, 1.5 million new cases in China. About 80% cases occurred in rural area, with an enormous amount of delayed or failed diagnosis.</p>
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<p>Case detection is currently the rate-limiting step in disease control. A diagnostic tool with high sensitivities and specificities is desired urgently, and it is supposed to be used at the point-of-care (POC) within a clinic or in the community. </p>
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<p>To obviate such problems, Peking iGEM team is developing a novel <!--<i>Mycobacterium tuberculosis</i>-->pathogen detection system that can transform biomarkers of the disease into optical signal or electric signal. Combined with our work in software and hardware development, we believe this new advanced system can be turned out as a powerful tool in disease diagnosis, with high sensitivities and specificities.</p>
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                            <li>
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                                <a href="https://2015.igem.org/Team:Peking/JudgingCriteria">Achievements</a>
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                                <ul class="dropdown">
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                                    <li><a href="https://2015.igem.org/Team:Peking/JudgingCriteria">Judging Criteria</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Parts">Parts</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Collaborations">Collaborations</a>
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                                <a href="https://2015.igem.org/Team:Peking/Design">Project</a>
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                                <ul class="dropdown">
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                                    <li><a href="https://2015.igem.org/Team:Peking/Design">Overview</a>
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                                    </li>
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<li><a href="https://2015.igem.org/Team:Peking/Design/PC_Reporter">Paired<span style="text-transform:lowercase"> d</span>Cas9 Reporter</a>                                   
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                                    <li><a href="https://2015.igem.org/Team:Peking/Design/Isothermal">Iso-<span style="text-transform:lowercase">t</span>hermal Amplification</a></li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Device">Hardware</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Design/Speculation">Speculation</a>
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                                <a href="https://2015.igem.org/Team:Peking/Modeling">Modeling</a>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Modeling">Array Design</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Modeling/Analysis">Analysis Algorithm</a>
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                                <a href="https://2015.igem.org/Team:Peking/Practices">Practices</a>
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                                <ul class="dropdown">
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                                    <li><a href="https://2015.igem.org/Team:Peking/Practices">Overview</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Practices/Background">TB Facts</a>
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                                    </li>
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                                    <li><a  href="https://2015.igem.org/Team:Peking/Practices/Consultation">Consultation and Interview</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Practices/Engagement">Public Engagement</a>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Practices/Outreach">Ethics and Economics Issues</a>
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                                <a href="https://2015.igem.org/Team:Peking/Team">Lab</a>
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                                <ul>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Team">Team</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Notebook">Notebook</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Attributions">Attributions</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Safety">Safety</a>
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                                    </li>
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      <h3 align="center" style="font-size:24px;color:#00afd1;"> Project Description</h3>
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      <div id="project-description" class="title-desc" style="max-width:75%; margin:auto;">
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        <p>Tuberculosis, caused by <i>Mycobacterium tuberculosis</i>, remains one of the world's most serious public health problems. Although tuberculosis is curable and the treatment success rate is high, it is still the second most common cause of death from infectious disease (after HIV). It causes more than 1.3 million deaths annually, and most of the deaths occur in developing countries that are lack of effective identification of those in need of therapy, with an enormous amount of delayed or failed diagnosis.<br></p>
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        <p><br/>Case detection is currently the rate-limiting step in disease control. The available Nucleic Acid Detection (NAD) Method is sensitive and fast, but does not reach the requirement of specificity and reliability.<br>  
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      <p><br/>To obviate such problems, Peking iGEM team is developing a novel PC Reporters system that can transform biomarkers of the disease into optical signal. Combined with array design and statistical analysis, the presence of <i>Mycobacterium tuberculosis</i> can be easily verified. It can also be easily used in developing areas with designed hardware development. We believe this new advanced system can turn  out as a powerful tool in disease diagnosis, with high specificity and reliability.  
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            <h3 style="font-size:24px"><span class="accent-color">Awards</span></br>
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                          Best New Composite Part<br/>
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              Best Part Collection
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            </h3>
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            <h3 style="font-size:24px"><span class="accent-color">Poster</span></br>
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            97 - Zone 4 - Hall C</br>
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            <span class="accent-color">Presentation</span></br>
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            9/26/2015 - Room 302 - 11:30 AM
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            </h3>
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            <p class="title-desc" style="margin-top:30px; font-size:22px;font-weight:bold" >Thanks for your attention!</p>
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                <a href="https://2015.igem.org/Team:Peking/Design/PC_Reporter"><img src="https://static.igem.org/mediawiki/2015/3/32/Peking-feature-1.png" style="max-width:180px"></a>
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              </div>
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              <div>
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                <p align="center" style="margin-top:10px"><b>Specificity</b></p>
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                <p style="padding-left:5px;padding-right:5px">A nucleic-acid-based, sequence-specific detection system named "paired dCas9" (PC) reporter was built. Its specificity and sensitivity proved to be enough to detect real MTB genome.</p>
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                <a href="https://2015.igem.org/Team:Peking/Design/PC_Reporter#array"><img src="https://static.igem.org/mediawiki/2015/7/79/Peking-feature-2.png" style="max-width:180px"></a>
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              </div>
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              <div>
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                <p align="center" style="margin-top:10px"><b>Reliability</b></p>
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                <p style="padding-left:5px;padding-right:5px">An array of MTB-specific markers was designed to use information from the entire genome of MTB to improve the reliability of diagnosis. By statistics, we are able to present the readouts in a quantitative way.</i></p>
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              </div>
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            </div>
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            <div class="col-md-3">
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                <a href="https://2015.igem.org/Team:Peking/Device"><img src="https://static.igem.org/mediawiki/2015/0/0c/Peking-feature-3.png" style="max-width:180px"></a>
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              </div>
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              <div>
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                <p align="center" style="margin-top:10px"><b>Portability</b></p>
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                <p style="padding-left:5px;padding-right:5px">Noticing that most TB cases occur in developing areas, we built an electronic device that was portable, affordable, and easy to use.</p>
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              </div>
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            </div>
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            <div class="col-md-3">
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              <div  align="center">
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                <a href="https://2015.igem.org/Team:Peking/Practices"><img src="https://static.igem.org/mediawiki/2015/2/2a/Peking-feature-4.png" style="max-width:180px"></a>
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              </div>
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              <div>
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                <p align="center" style="margin-top:10px"><b>Bench to Bedside</b></p>
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                <p style="padding-left:5px;padding-right:5px">Coming from bedside to bench, we set out to apply our bench achievements back to bedside. With consultation, survey and feedback from clinical practice, we are still working on improving our detection system!</p>
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              <a href="https://2015.igem.org/Team:Peking/Design/PC_Reporter"><i class="fa"><img src="https://static.igem.org/mediawiki/2015/3/32/Peking-feature-1.png" style="max-width:50%"></i></a>
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            </div>
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            <div class="service-content">
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              <h4>Specificity</h4>
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              <p><br>Designed the novel Paired dCas9 (PC) Reporter system to improve the specificty and tested on <span style="color:#00afd1">real TB genome</span>.</p>
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              <h4>Reliability</h4>
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              <p><br>Combine <span style="color:#00afd1">array design</span> and <span style="color:#00afd1">statistical analysis</span> to verify the presence of <i>Mycobacterium tuberculosis</i>.</p>
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              <h4>Portability</h4>
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              <p>Designed a <span style="color:#00afd1">cheap and portable</span> prototype to be used in developing regions.</p>
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Latest revision as of 12:42, 17 November 2015

Peking iGEM 2015

Project Description

Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the world's most serious public health problems. Although tuberculosis is curable and the treatment success rate is high, it is still the second most common cause of death from infectious disease (after HIV). It causes more than 1.3 million deaths annually, and most of the deaths occur in developing countries that are lack of effective identification of those in need of therapy, with an enormous amount of delayed or failed diagnosis.


Case detection is currently the rate-limiting step in disease control. The available Nucleic Acid Detection (NAD) Method is sensitive and fast, but does not reach the requirement of specificity and reliability.


To obviate such problems, Peking iGEM team is developing a novel PC Reporters system that can transform biomarkers of the disease into optical signal. Combined with array design and statistical analysis, the presence of Mycobacterium tuberculosis can be easily verified. It can also be easily used in developing areas with designed hardware development. We believe this new advanced system can turn out as a powerful tool in disease diagnosis, with high specificity and reliability.

Awards
Best New Composite Part
Best Part Collection

Poster
97 - Zone 4 - Hall C
Presentation
9/26/2015 - Room 302 - 11:30 AM

Thanks for your attention!

Specificity

A nucleic-acid-based, sequence-specific detection system named "paired dCas9" (PC) reporter was built. Its specificity and sensitivity proved to be enough to detect real MTB genome.

Reliability

An array of MTB-specific markers was designed to use information from the entire genome of MTB to improve the reliability of diagnosis. By statistics, we are able to present the readouts in a quantitative way.

Portability

Noticing that most TB cases occur in developing areas, we built an electronic device that was portable, affordable, and easy to use.

Bench to Bedside

Coming from bedside to bench, we set out to apply our bench achievements back to bedside. With consultation, survey and feedback from clinical practice, we are still working on improving our detection system!