Difference between revisions of "Team:Colegio EmelinaU/Modeling"

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<h1>Description: </h1>
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<h1>Modeling<h1>
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As we all know the UV rays are present all the year round, it is known that young people about 18 years old have received 80% of the radiation that would absorb during their whole life.
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<img class="imagen" src="https://static.igem.org/mediawiki/2015/f/f4/Img_portada.jpg"><p>According to the Ministry of Health in Chile in the last 5 years there have been 20-25 cases of skin cancer per 100 inhabitants. One of the main factors causing skin cancer is the ultraviolet radiation (UV). This is a natural radiation which in low dose is harmless to the cells, even it can be beneficial for an organism survival. However, when a certain amount is exceeded, it can cause a serious cell damage. The highest levels of UV radiation are reported in Chile.
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Our team proposes a system that alerts the intensity of UV radiation. In detail, the project it is represented in a bracelet which it is composed by Bacillus subtilis bacteria that is modified genetically with a system that senses ultraviolet light and according to the intensity it generate the correct coloration . This will allow people to protect themselves from UV rays when its intensity is harmful for the cells.</p>
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The main cause of the signs of aging is the UVA rays, some of those signs are wrinkles and loss of elasticity in the skin. These rays also have interference in non-melanoma cancers as CCE.
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UV radiation causes skin damage, so we focus on creating an alert, that is not going to be used only on sunny days, but throughout the year, since, it is known that 40% of the radiation occurs when we are not at full sunlight.
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In the picture, we see the linear graph model based on two plasmids , in which you can observe the promoter , terminator , RBS and the sequence of interest , which when we put them together, they form a more complex system. In the linear we can see how our BrioBricks relate to each other.
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The constitutive promoter, expresses the sequence producing the protein dimer that joined to the tetR suppresses the second plasmid promoter and to the contact with the sun rays, generates a structure change, becoming in a monomer which allows that the RNA polymerase to connect to the promoter, our chromo protein be transcribed and our blue color is generated.
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Revision as of 05:34, 16 September 2015

Description:

According to the Ministry of Health in Chile in the last 5 years there have been 20-25 cases of skin cancer per 100 inhabitants. One of the main factors causing skin cancer is the ultraviolet radiation (UV). This is a natural radiation which in low dose is harmless to the cells, even it can be beneficial for an organism survival. However, when a certain amount is exceeded, it can cause a serious cell damage. The highest levels of UV radiation are reported in Chile. Our team proposes a system that alerts the intensity of UV radiation. In detail, the project it is represented in a bracelet which it is composed by Bacillus subtilis bacteria that is modified genetically with a system that senses ultraviolet light and according to the intensity it generate the correct coloration . This will allow people to protect themselves from UV rays when its intensity is harmful for the cells.