Difference between revisions of "Team:Harvard BioDesign"
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once the bacteria are localized on the cells, the next step is to make the <E. coli</i> capable of producing a concentrated toxin or to administer a therapeutic. | once the bacteria are localized on the cells, the next step is to make the <E. coli</i> capable of producing a concentrated toxin or to administer a therapeutic. | ||
Other potential applications for our <i>E. coli </i> include water pollution clean up through methods such as flocculation and targeting areas through GFP.</p> | Other potential applications for our <i>E. coli </i> include water pollution clean up through methods such as flocculation and targeting areas through GFP.</p> | ||
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Revision as of 14:49, 15 July 2015
Welcome to the Harvard BioDesign's 2015 Team Wiki!
Our team is engineering E. Coli to bind to colon cancer cells through the use of their type I pili, which are hair-like appendages
that have an adhesive domain. Naturally, the strains in E. coli that produce pili bind to alpha-D-mannose, which can cause urinary track infections.
However, our team is altering a non-harmful strain to produce pili using a modified Fim gene in order to localize the bacteria as a tool. For treatment of cancer,
once the bacteria are localized on the cells, the next step is to make the
