Revision as of 15:58, 18 August 2015

"What I cannot create I do not understand."
- Richard Feynmann

Full Model

Target mammalian cell located in the center of the well
Constant rate of lactate production
E. coli bound to target cell abstracted into homogeneous layer around target cell
Two different forms of unbound E. coli

Lactate represented as two states: inside and outside E. coli, denoted \(Lac_{int}\) and \(Lac_ext\), respectively

\(Lac_{int}\) can diffuse freely through medium and membranes, \(Lac_{ext}\) cannot
Use to simulate different import and export rates of lactate into E. coli

@@ Line 13: / Line 13: @@
 <li>Constant rate of lactate production</li>
 <li><i>E. coli</i> bound to target cell abstracted into homogeneous layer around target cell</li>
-<li>Lactate represented as two states: inside and outside <i>E. coli</i>, denoted $Lac_int$ and $Lac_ext$, respectively</li>
+<li>Two different forms of unbound <i>E. coli</i></li>
 <ul>
-<li>$Lac_int$ can diffuse freely through medium and membranes, $Lac_ext$ cannot</li>
+<li>Discrete: single cell of <i>E. coli</i> suspended in the medium</li>
+<li>Bulk: reactions of the rest of the <i>E. coli</i> simulated in same space as medium</li>
+</ul>
+<li>Lactate represented as two states: inside and outside <i>E. coli</i>, denoted \(Lac_{int}\) and \(Lac_ext\), respectively</li>
+<ul>
+<li>\(Lac_{int}\) can diffuse freely through medium and membranes, \(Lac_{ext}\) cannot</li>
 <li>Use to simulate different import and export rates of lactate into <i>E. coli</i></li>
 </ul>
+<li>Bulk <i>E. coli</i> grow logistically</li>
 </ul>
 <h3>Results</h3>