Difference between revisions of "Team:ETH Zurich/Modeling/Reaction-diffusion"
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<li>Bulk: reactions of the rest of the <i>E. coli</i> simulated in same space as medium</li> | <li>Bulk: reactions of the rest of the <i>E. coli</i> simulated in same space as medium</li> | ||
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| − | <li>Lactate represented as two states: inside and outside <i>E. coli</i>, denoted \(Lac_{int}\) and \( | + | <li>Lactate represented as two states: inside and outside <i>E. coli</i>, denoted \(Lac_{int}\) and \(Lac_{ext}\), respectively</li> |
<ul> | <ul> | ||
<li>\(Lac_{int}\) can diffuse freely through medium and membranes, \(Lac_{ext}\) cannot</li> | <li>\(Lac_{int}\) can diffuse freely through medium and membranes, \(Lac_{ext}\) cannot</li> | ||
Revision as of 16:04, 18 August 2015
- Project
- Modeling
- Lab
- Human
Practices - Parts
- About Us
Full Model
1D model in MATLAB
3D model in COMSOL with reaction-diffusion
Four cases
Assumptions
- Target mammalian cell located in the center of the well
- Constant rate of lactate production
- E. coli bound to target cell abstracted into homogeneous layer around target cell
- Two different forms of unbound E. coli
- Discrete: single cell of E. coli suspended in the medium
- Bulk: reactions of the rest of the E. coli simulated in same space as medium
- Lactate represented as two states: inside and outside E. coli, denoted \(Lac_{int}\) and \(Lac_{ext}\), respectively
- \(Lac_{int}\) can diffuse freely through medium and membranes, \(Lac_{ext}\) cannot
- Use to simulate different import and export rates of lactate into E. coli
- Bulk E. coli grow logistically