Difference between revisions of "Team:Harvard BioDesign/Project"

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<h4> Content </h4>
 
<h4> Content </h4>
 
             <ul>
 
             <ul>
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                 <li><a href="#introduction" id="top-link" class="skel-layers-ignoreHref"><span class="icon fa-home">Introduction</span></a></li>
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                 <li><a href="#introduction" id="top-link" class="skel-layers-ignoreHref"><span class="icon fa-home">Background</span></a></li>
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                 <li><a href="#foundations" id="overview-link" class="skel-layers-ignoreHref"><span class="icon fa-th">Foundations</span></a></li>
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                 <li><a href="#foundations" id="overview-link" class="skel-layers-ignoreHref"><span class="icon fa-th">Platform</span></a></li>
 
                 <li><a href="#applications" id="sitemap-link" class="skel-layers-ignoreHref"><span class="icon fa-user">Applications</span></a></li>
 
                 <li><a href="#applications" id="sitemap-link" class="skel-layers-ignoreHref"><span class="icon fa-user">Applications</span></a></li>
 
             </ul>
 
             </ul>
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             <div class="container">
 
             <div class="container">
 
<img src="https://static.igem.org/mediawiki/2015/8/85/Harvard_2015_Project.png" alt="Project Logo" style="width:200px;height:200px;"/>
 
<img src="https://static.igem.org/mediawiki/2015/8/85/Harvard_2015_Project.png" alt="Project Logo" style="width:200px;height:200px;"/>
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<header><h2>BactoGrip: About our project</h2></header>
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<header><h2>BactoGrip: Where we began</h2></header>
  
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               <p>Our team is engineering <i>E. coli</i> to bind to colon cancer cells through the use of their type I pili, which are hair-like appendages
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               <p>
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              that have an adhesive domain. Naturally, the strains in <i>E. coli</i> that produce pili bind to alpha-D-mannose, which can cause urinary tract infections.
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                Colon cancer is the second leading cause of cancer death in the United States. Each year, almost 140,000 people
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              However, our team is altering a non-harmful strain to produce pili using a modified Fim gene in order to localize the bacteria as a tool. For treatment of cancer,
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                are diagnosed with colon cancer, and 50,000 people die from the disease. Diagnosis and treatment often require invasive
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              once the bacteria are localized on the cells, the next step is to make them <E. coli</i> capable of producing a concentrated toxin or to administer a therapeutic.
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                procedures, including colonoscopies and surgery. Less invasive treatments such as chemotherapy cause unpleasant side
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              Other potential applications for our <i>E. coli </i> include water pollution clean up through methods such as flocculation and targeting areas through GFP.</p>
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                effects. We turn to synthetic biology to develop a better colon cancer therapy. An ideal cell-based therapy would have
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                two significant components: a way to kill cancer cells, and a way to specifically target them. In our quest to find a way
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                to specifically target cancer cells, we found that the problem of controlling a cell’s interaction with its physical
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                environment extended beyond cancer therapy into a myriad of biological contexts. Harvard iGEM 2015 focuses on building a
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                platform for controlling specific bacterial adhesion in a variety of biological settings, including colon cancer therapy.
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              </p>
  
 
             <footer>How do you use BactoGrip, you ask?<br/>
 
             <footer>How do you use BactoGrip, you ask?<br/>
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</div>
 
</div>
 
             </footer>
 
             </footer>
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            </div>
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          </section>
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          <section class="two">
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            <div class = "container">
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              <header><h2>Looking Closely at the Problem</h2></header>
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             </div>
 
             </div>
 
           </section>
 
           </section>
  
 
         <!-- Experiments -->
 
         <!-- Experiments -->
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           <section id="foundations" class="two">
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           <section id="foundations" class="three">
 
             <div class="container">
 
             <div class="container">
  
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         <!-- Design -->
 
         <!-- Design -->
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           <section id="applications" class="three">
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           <section id="applications" class="four">
 
             <div class="container">
 
             <div class="container">
  

Revision as of 03:44, 18 September 2015


Prologue by HTML5 UP

Project Logo

BactoGrip: Where we began

Colon cancer is the second leading cause of cancer death in the United States. Each year, almost 140,000 people are diagnosed with colon cancer, and 50,000 people die from the disease. Diagnosis and treatment often require invasive procedures, including colonoscopies and surgery. Less invasive treatments such as chemotherapy cause unpleasant side effects. We turn to synthetic biology to develop a better colon cancer therapy. An ideal cell-based therapy would have two significant components: a way to kill cancer cells, and a way to specifically target them. In our quest to find a way to specifically target cancer cells, we found that the problem of controlling a cell’s interaction with its physical environment extended beyond cancer therapy into a myriad of biological contexts. Harvard iGEM 2015 focuses on building a platform for controlling specific bacterial adhesion in a variety of biological settings, including colon cancer therapy.

Looking Closely at the Problem

Foundations

Applications