Difference between revisions of "Team:San Andres/Description"

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      <a href="https://2015.igem.org/Team:San_Andres"
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style="color: rgb(0, 0, 0);"> Team </a> </td>
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       <a href="https://2015.igem.org/Team:San_Andres/Description"
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style="color: rgb(0, 0, 0);"> Project </a>
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       <a href="https://2015.igem.org/Team:San_Andres/Notebook"
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style="color: rgb(0, 0, 0);"> Statistics</a>
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       <a href="https://2015.igem.org/Team:San_Andres/Experiments"
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style="color: rgb(0, 0, 0);"> Enzymes</a>
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style="color: rgb(0, 0, 0);"> Parts</a>
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      <a href="https://2015.igem.org/Team:San_Andres/Notebook"
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style="color: rgb(0, 0, 0);"> Metodology</a>
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       <a href="https://2015.igem.org/Team:San_Andres/Results"
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      <a href="https://2015.igem.org/Team:San_Andres/Collaborations"
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       <a href="https://igem.org/Team_List?year=2015"><img
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<h1>Project&nbsp;</h1>
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class="gwd-span-fn2e">Our project is about&nbsp;</span><span
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+
class="gwd-span-a1dh"><span class="gwd-span-6ea3"
−
   </style>
+
lang="EN-US"><span style="">celiac</span></span>
−
  <div class="gwd-div-wbgu"><span class="gwd-span-3t71"><p class="MsoNormal gwd-p-wkuc"><span class="gwd-span-fn2e">Our project is about&nbsp;</span><span class="gwd-span-a1dh"><span style=""><span lang="EN-US" class="gwd-span-6ea3"><span style="">celiac</span></span>
+
<span class="gwd-span-xrze"><span class="gwd-span-bh3g"
−
    </span><span class="gwd-span-xrze"><span lang="EN-US" class="gwd-span-bh3g">&nbsp;</span><span class="gwd-span-1fs0"><span lang="EN-US" class="gwd-span-5vwr"><span style="">disease, this is a
+
lang="EN-US">&nbsp;</span><span
−
enteropathy, autoimmune affecting individuals who possess genes HLA-DQ8 or
+
class="gwd-span-1fs0"><span class="gwd-span-5vwr"
−
HLA-DQ2, where T cells attack the body when the gliadins and glutenins are
+
lang="EN-US"><span style="">disease, this is a
−
absorbed by the small intestine, in others words, celiac patients have a
+
enteropathy, autoimmune affecting individuals who possess genes HLA-DQ8
−
permanent intolerance to gluten-containing foods</span></span>
+
or
−
    </span><span lang="EN-US" class="gwd-span-1haj">.</span><span lang="EN-US" class="gwd-span-xku1"><o:p></o:p></span></span>
+
HLA-DQ2, where T cells attack the body when the gliadins and glutenins
−
    </span>
+
are
−
    </p>
+
absorbed by the small intestine, in others words, celiac patients have
−
    <img src="https://static.igem.org/mediawiki/2015/4/44/Symptoms_of_celiac_disease.jpg" class="gwd-img-c7yq">
+
a
−
    <div class="gwd-div-6ky8"></div>
+
permanent intolerance to gluten-containing foods</span></span></span><span
−
    <div class="gwd-div-2b5b"><span class="gwd-span-u82g">The damage caused by the autoimmune reaction can cause histological&nbsp;damage in the villi, and a biopsy of these is the means of diagnosis of this pathology. The only current treatment is a diet without gluten, which is expensive and difficult to follow</span>
+
class="gwd-span-1haj" lang="EN-US">.</span></span></span></span></big><br>
−
    </div>
+
<br>
−
    <div class="gwd-div-rxi8"><span class="gwd-span-oxe1">This is the tip of the iceberg of celiac disease, the symptoms as are easy to diagnose, but there are other four ways where the symptoms are not so clear. These forms are:<br class="gwd-br-q8fj"></span>
+
<div style="text-align: center;"><img
−
      <ol class="gwd-ol-ewzq">
+
src="https://static.igem.org/mediawiki/2015/a/ad/Enteropatia.jpg"
−
        <li class="gwd-li-cx4k"><span class="gwd-span-bp36">Silent Celiac Disease: Patients have no symptoms but if damage histological.</span>
+
class="gwd-img-tdba"><br>
−
        </li>
+
<br>
−
        <li class="gwd-li-83gw"><span class="gwd-span-y410">Latent Celiac Disease: There are not symptoms and stunted villi. Individuals tend to develop the disease suddenly.</span>
+
<div style="text-align: left;"><big><span
−
        </li>
+
class="gwd-span-nj86">When the gluten to come into contact
−
        <li class="gwd-li-hrrk"><span class="gwd-span-9f33">Potential Celiac Disease: Are subjects with high genetic risk that could have the disease.</span>
+
with the villi of the small intestine (enterocytes), the cells helper
−
        </li>
+
(type of reporter) detected the gluten like as a toxic substance and
−
        <li class="gwd-li-7d5y"><span class="gwd-span-juom">Refractory Celiac Disease: Those patients diagnosted celiac and despite follow a diet without gluten doesn't improve and can get diseases even more serious.</span>
+
leave a footprint chemistry, which is followed by antibodies and
−
        </li>
+
lymphocytes T and B. The first are the natural killer and an army of
−
      </ol>
+
these cells attack the infected cells, which could cause a carcinogen
−
    </div>
+
effect, in this case the dangerous cells are the enterocytes, causing
−
    <img src="https://static.igem.org/mediawiki/2015/3/37/Iceberg_CD.jpg" class="gwd-img-74jg">
+
inflammation, poor absorption, and other symptoms.</span></big></div>
−
    <div class="gwd-div-nqxo"></div>
+
</div>
−
    <div class="gwd-div-37ul"><span class="gwd-span-h4j2">The celiac disease are associated with many diseases, these can also be complications of refractory patients.</span>
+
<span class="gwd-span-3t71"><span class="gwd-span-a1dh"><span
−
    </div>
+
class="gwd-span-xrze"><span class="gwd-span-1haj"
−
    <img src="https://static.igem.org/mediawiki/2015/c/c3/Complications.jpg" class="gwd-img-4j8q">
+
lang="EN-US">&nbsp;<br>
−
    </span>
+
</span></span></span></span>
−
    <img src="https://static.igem.org/mediawiki/2015/a/ad/Enteropatia.jpg" class="gwd-img-tdba">
+
<div style="text-align: center;"><img
−
    <div class="gwd-div-fjcw"></div>
+
src="https://static.igem.org/mediawiki/2015/4/44/Symptoms_of_celiac_disease.jpg"
−
  </div>
+
class="gwd-img-c7yq"><br>
−
  <div class="gwd-div-7fn5"><span class="gwd-span-nj86">When the gluten to come into contact with the villi of the small intestine (enterocytes), the cells helper (type of reporter) detected the gluten like as a toxic substance and leave a footprint chemistry, which is followed by antibodies and lymphocytes T and B. The first are the natural killer and an army of these cells attack the infected cells, which could cause a carcinogen effect, in this case the dangerous cells are the enterocytes, causing inflammation, poor absorption, and other symptoms.</span>
+
<br>
−
  </div>
+
<div style="text-align: left;"><span
−
  <img src="https://static.igem.org/mediawiki/2015/0/0a/Histological_study.jpg" class="gwd-img-5j7g">
+
class="gwd-span-3t71"><span class="gwd-span-u82g"><big>The
−
  <img src="https://static.igem.org/mediawiki/2015/c/c3/Sin-gluten.jpg" class="gwd-img-24d5">
+
damage caused by the autoimmune reaction can cause
 +
histological&nbsp;damage in the villi, and a biopsy of these is the
 +
means of diagnosis of this pathology. The only current treatment is a
 +
diet without gluten, which is expensive and difficult to follow.</big><br>
 +
<br>
 +
</span></span>
 +
<div style="text-align: center;"><span
 +
class="gwd-span-3t71"><span class="gwd-span-u82g">&nbsp;</span></span><img
 +
src="https://static.igem.org/mediawiki/2015/0/0a/Histological_study.jpg"
 +
class="gwd-img-5j7g"><br>
 +
</div>
 +
<br>
 +
<span class="gwd-span-3t71">
 +
<div class="gwd-div-rxi8"><big><span
 +
class="gwd-span-oxe1">This is the tip of the iceberg of
 +
celiac disease, the symptoms as are easy to diagnose, but there are
 +
other four ways where the symptoms are not so clear. These forms are:<br
 +
class="gwd-br-q8fj">
 +
</span></big>
 +
<ol class="gwd-ol-ewzq">
 +
  <li class="gwd-li-cx4k"><big><span
 +
class="gwd-span-bp36">Silent Celiac Disease: Patients have
 +
no symptoms but if damage histological.</span> </big></li>
 +
  <li class="gwd-li-83gw"><big><span
 +
class="gwd-span-y410">Latent Celiac Disease: There are not
 +
symptoms and stunted villi. Individuals tend to develop the disease
 +
suddenly.</span> </big></li>
 +
  <li class="gwd-li-hrrk"><big><span
 +
class="gwd-span-9f33">Potential Celiac Disease: Are subjects
 +
with high genetic risk that could have the disease.</span> </big></li>
 +
  <li class="gwd-li-7d5y"><big><span
 +
class="gwd-span-juom">Refractory Celiac Disease: Those
 +
patients diagnosted celiac and despite follow a diet without gluten
 +
doesn't improve and can get diseases even more serious.</span></big></li>
 +
</ol>
 +
<div style="text-align: center;"><img
 +
src="https://static.igem.org/mediawiki/2015/3/37/Iceberg_CD.jpg"
 +
class="gwd-img-74jg"><br>
 +
<br>
 +
<div style="text-align: left;"><big><span
 +
class="gwd-span-3t71"><span class="gwd-span-h4j2">The
 +
celiac disease are associated with many diseases, these can also be
 +
complications of refractory patients.</span></span><br>
 +
</big><br>
 +
<div style="text-align: center;"><img
 +
src="https://static.igem.org/mediawiki/2015/c/c3/Complications.jpg"
 +
class="gwd-img-4j8q"> </div>
 +
</div>
 +
</div>
 +
</div>
 +
</span></div>
 +
</div>
 +
<br>
 +
<br>
 +
&nbsp;&nbsp;<br>
 +
<br>
 +
<strong></strong></div>
 +
<br>
 +
<div class="gwd-div-a9c8"></div>
 +
<br>
 
</body>
 
</body>
−
 
 
</html>
 
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Revision as of 19:28, 5 July 2015

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Project 

Our project is about celiac  disease, this is a enteropathy, autoimmune affecting individuals who possess genes HLA-DQ8 or HLA-DQ2, where T cells attack the body when the gliadins and glutenins are absorbed by the small intestine, in others words, celiac patients have a permanent intolerance to gluten-containing foods.



When the gluten to come into contact with the villi of the small intestine (enterocytes), the cells helper (type of reporter) detected the gluten like as a toxic substance and leave a footprint chemistry, which is followed by antibodies and lymphocytes T and B. The first are the natural killer and an army of these cells attack the infected cells, which could cause a carcinogen effect, in this case the dangerous cells are the enterocytes, causing inflammation, poor absorption, and other symptoms.
 


The damage caused by the autoimmune reaction can cause histological damage in the villi, and a biopsy of these is the means of diagnosis of this pathology. The only current treatment is a diet without gluten, which is expensive and difficult to follow.
 

This is the tip of the iceberg of celiac disease, the symptoms as are easy to diagnose, but there are other four ways where the symptoms are not so clear. These forms are:
  1. Silent Celiac Disease: Patients have no symptoms but if damage histological.
  2. Latent Celiac Disease: There are not symptoms and stunted villi. Individuals tend to develop the disease suddenly.
  3. Potential Celiac Disease: Are subjects with high genetic risk that could have the disease.
  4. Refractory Celiac Disease: Those patients diagnosted celiac and despite follow a diet without gluten doesn't improve and can get diseases even more serious.


The celiac disease are associated with many diseases, these can also be complications of refractory patients.