Difference between revisions of "Team:Hong Kong-CUHK/Attributions"

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<h1>Magnetosome - Nanostructure with Great Application Potentials</h1>
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<p align="right"> Figure 1: Magnetosome </p>
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<p align="right"><i>Together we are, </i><b>CUHK iGEM TEAM 2015</b></p>
 
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<p style="margin-bottom: 1.5em">Magnetosome is a kind of rare intracellular membrane-bound structure in a specific type of prokaryotes, of nano-size ranging about 35 - 120 nm. They comprise of a magnetic mineral crystal encapsulated by a lipid bilayer about 3 – 4 nm thick (Figure 1) [1], which might be utilized in various applications involving magnetic field. </p>
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The magnetosome membrane is highly significant for its biogenesis as it creates an isolated environment within the cell crucial for mineral crystal nucleation and growth [2]. These inorganic crystals are magnetic in nature (hence its name), which compose of either magnetite (Fe<sub>3</sub>O<sub>4</sub>) or greigite (Fe<sub>3</sub>S<sub>4</sub>). The magnetosomes usually arrange in one or multiple chains along the cell axis. Different varieties of crystal morphologies such as cubo-octahedral, elongated hexagonal prismatic, and bullet-shaped morphologies were discovered in different magnetotactic bacteria [1].</p>
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<h3>Members United: </h3>
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    <img src = "https://static.igem.org/mediawiki/2015/c/c0/CUHK_Team_Leader_Louis.jpeg" height ="300px" align="left" style="margin:0px 20px 0px 0px">
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    <h3><font face="Calibri" size="5pt">Team Captain: Louis</h3></font>
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    <p><font face="Calibri"size="4pt">Hi!I am Louis, a year two biochemistry student in The Chinese University of Hong Kong (CUHK) and team leader this year. Welcome to our wiki page and hope our project interest you. If you have questions about our project or just want to chat with us :P, feel free to contact us. See you in the Great Jamboree.</font>
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    <h3>Vice Team Captain: Sharon</h3>
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    <p>Hey there! I am Sharon, a year 3 undergraduate student majoring in Biochemistry. Participating in IGEM has been very exciting, and I am looking forward to meeting other teams from all over the world!!!
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<h1>Magnetotactic Bacteria - The Magnetosome Producer </h1>
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<p align="left" padding="10">Figure 2: Micrograph of a Magnetotactic Bacteria, <i>Magnetospirillum gryphiswaldense</i> (image from Departamento de Inmunología, Microbiología y Parasitología, University of the Basque Country) </p>
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<p style="margin-bottom: 1.5em">Magnetosomes are organelles synthesized by magnetotactic bacteria for its movement along magnetic field. These magnetotactic bacteria are mobile, aquatic, gram-negative prokaryotes [3] with an array of cellular morphologies, including coccoid, rod-shaped, vibrioid, helical or even multi-cellular. Some of them are more extensively studied, including <i>Magnetospirillum magnetotacticum</i> and <i>Magnetospirillum gryphiswaldense</i>. They are found optimally grown at the oxic-anoxic interface in aquatic habitats, and in fact grow less happily under atmospheric oxygen concentration.</p>
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<p style="margin-bottom: 1.5em">Magnetosomes form a chain and are aligned along the axis within the bacteria. With these magnetosomes inside them, they are able to align passively to the earth’s magnetic field so as to swim along geomagnetic field lines. This behaviour is called magnetotaxis and is beneficial to their survival by aiding them to reach regions of optimal oxygen concentrations at minimal energy cost [4]. </p>
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    <h3>Vice Team Captain: Alex</h3>
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    <p>Hi, I am Alex, a year 2 biomedical engineering student. I am keen on lab and I believe that DNA, such a small thing can change the world. Thankfully I can see the world through the IGEM competition.
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<h1> <i>Azotobacter vinelandii</i> - What and Why? </h1>
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    <img src = "https://static.igem.org/mediawiki/2015/6/61/CUHK_Self_Intro_Gigi.jpg" height ="300px" align="right" style="margin:0px 0px 0px 20px"><h3>Secretary: Gigi</h3>
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Hi everyone, I am Gigi, a year 2 biochemistry teenager. Igem is such an exciting platform for one to generate and execute any creative ideas. Not only can I apply what I have learnt in lectures but also i can learn a lot through own exploration and through team buddies from many other disciplines. This is so cool ~♡
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    <img src = "https://static.igem.org/mediawiki/2015/c/c7/CUHK_Self_Intro_Henry.jpg" height ="450px" align="left" style="margin:0px 20px 0px 0px"><h3>Treasurer: Henry</h3>
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<p>Second year student studying molecular biotechnology. </p>
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<p>I participate in iGEM 2015 as I am interested in synthetic biology and it also provides an opportunity to meet people from all over the world during the competition. </p>
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<p style="margin-bottom: 1.5em">Although magnetotactic bacteria produces magnetosomes, these bacteria are notorious for the difficulty to cultivate owing to their micro-aerophilic nature. Elaborate growth techniques are required, and they are difficult to grow on the surface of agar plates, introducing problems in mutant screening [5]. </p>
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    <img src = "https://static.igem.org/mediawiki/2015/1/1b/CUHK_Self_Intro_Alyssa.jpg" height ="350px" align="right" style="margin:0px 0px 0px 20px"><h3>Wet Lab Team: Alyssa</h3>
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Hi, I am Alyssa, a year three biochemistry student. I am glad to join IGEM2015. Teammates, knowledge are the precious things I have gained from IGEM. Work hard, play harder!
  
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<p style="margin-bottom: 1.5em">The lack of effective methods of DNA transfer in these microorganisms is a challenge too. Luckily, the situation is improving due to better technologies recently and some of the genes from <i>M. magnetotacticum</i> were confirmed functionally expressed in <i>Escherichia coli</i>, a common lab bacteria strain. This shows that the transcriptional and translational elements of the two microorganisms are compatible. With such good news, a number of previous iGEM teams including Kyoto-2014, OCU-China-2013, Washington-2011 and UNIK_Copenhagen-2013 have been working with transferring the magnetosome-related genes to <i>E. coli</i>. Some exciting results about the formation of magnetosome membrane in <i>E. coli</i> (by the Kyoto-2014 team) has been reported, however, never the whole magnetosome.</p>
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<img src = "https://static.igem.org/mediawiki/2015/a/ac/CUHK_Project_Azotobacter_vinelandii.jpg" height ="250px" style="margin:0px 0px 0px 20px" align="right">
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<p align="right"> Figure 3: <i>Azotobacter vinelandii</i> </p>
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<p style="margin-bottom: 1.5em">We wonder why magnetosomes seem so hard to be formed in <i>E. coli</i>. And then, we come up with a hypothesis - the formation of magnetosome requires <b>a micro-aerobic or anaerobic environment</b> as the magnetotatic bacteria are all living micro-aerobically. </p>
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    <img src = "https://static.igem.org/mediawiki/2015/e/e2/CUHK_Self_Intro_Emily.jpg" height ="450px" align="left" style="margin:0px 20px 0px 0px"><h3>Wet Lab Team: Emily</h3>
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Hello! I’m Emily, a year 2 Biomedical Engineering student. The reason for me to join iGEM is to gain the experience of doing lab, because I am an engineering student which means I don’t have a lot of chances to do life science labs. I also learnt to cooperate with a team of members with different personalities. It's a unique experience!
  
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<p style="margin-bottom: 1.5em">Therefore, we chose a new bacteria to work on our magnetosome project - <b><i>Azotobacter vinelandii</i></b>. </p>
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<p style="margin-bottom: 1.5em"><i>A. vinelandii</i> is gram-negative diazotroph (nitrogen-fixing microorganism). It is a soil bacterium related to the <i>Pseudomonas</i> genus that fixes nitrogen under aerobic conditions while having enzymatic mechanisms protecting <b>its oxygen-sensitive nitrogenase</b> from oxidative damage. This finding shows that <i>A. vinelandii</i> could be an excellent host for the production and characterization of oxygen-sensitive proteins or organelles in our case [6]. </p>
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<p style="margin-bottom: 1.5em">With the biggest advantage of using <i>Azotobacter</i> that it being <b>an aerobe providing an intracellular anaerobic environment</b>, we can grow it easily in normal lab conditions without expensive equipments, while fulfilling the formation criteria for magnetosome. Besides, <b>most parts in registry are compatible in <i>Azotobacter</i></b> and it is of <b>safety level group 1</b>. One more important thing is that it can conduct <b>homologous recombination for stable genome integration</b>, which is a critical process we need in our project. </p><br>
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    <img src = "https://static.igem.org/mediawiki/2015/2/23/CUHK_Self_Intro_Jimmy.jpg" height ="450px" align="right" style="margin:0px 0px 0px 20px"><h3>Wet Lab Team: Jimmy</h3>
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Hi, I am Jimmy, a year2 science student form biochemistry major. I have chosen to join iGem team because I want to learn some techniques in doing experiment and learn how to work with others.
  
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<h1>Magnetosome Island Genes - Everything Required for Magnetosome Formation</h1>
 
  
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<p>For the synthesis of magnetosome, it is strictly controlled by a group of genes clustered in the magnetosome island (MAI). MAI comprise of four operons, namely <i>mms6</i>, <i>mamGFDC</i>, <i>mamAB</i> and <i>mamXY</i> operons [5]. The actual size and organisation of the MAI might differ between species, but the operons seems to be highly conserved within the MAI [2]. </p>
 
  
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<p>Through genetic mutants, researches has shown with the deletion of <i>mamAB</i> operon would lead to non-magnetic phenotype, showing the importance of <b><i>mamAB</i> operon as minimal requirement for magnetosome formation</b> and other important functions such as membrane invagination, iron transport, and magnetite biomineralization [7]. </p>
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<p>In the bacteria <i>Magnetospirillum gryphiswaldense</i>, the <i>mamAB</i> operon consists of 17 genes, namely <i>mamH, -I, -E, -J, -K, -L, -M, -N, -O, -P, -A, -Q, -R, -B, -S, -T, and -U</i>. </p>
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    <img src = "https://static.igem.org/mediawiki/2015/6/6a/CUHK_Self_Intro_Peter.jpg" height ="400px" align="left" style="margin:0px 20px 0px 0px"><h3>Wiki and Modeling Team: Peter </h3>
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Hi, everyone! I am Peter, year 2 student studying biomedical engineering. I am so passionate about genetic engineering and feel excited in participating iGEM 2015. It is a great opportunity for me to meet people from all over the world. It also leads me to explore new frontiers and gain perfect experience in different biological perspective.
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<h1>Biogenesis of Magnetosome</h1>
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<p>Now let's look at the biosynthesis of magnetosomes as a multistep complex process. </p>
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<h3>Wiki and Modeling Team: Angel</h3>
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Hello! I am a Year-3 Engineering student. I enjoy making new friends and working with my team members. I want to learn more and do research in the lab. I also want to make more friends from other countries. Therefore, I join the iGEM team and the experience is great.
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<img src = "https://static.igem.org/mediawiki/2015/c/c1/CUHK_Magnetosome_formation.jpg" width="500px" style="margin:-30px 0px 0px 20px" align="right">
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<p align="right"> Figure 4: Overview of Magnetosome Formation</p>
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    <img src = "https://static.igem.org/mediawiki/2015/e/ea/CUHK_Self_Intro_Matthew.jpg" height ="400px" align="left" style="image-orientation: rotate 90deg;
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-webkit-transform: rotate(90deg); -moz-transform: rotate(90deg); -o-transform: rotate(90deg); -ms-transform: rotate(90deg); position: relative; left: 20px; top: -15px; margin:0px 60px 0px 0px"><h3>Design Team: Matthew</h3>
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Hi! I am so excited to participate in iGEM 2015 CUHK team. It is definitely a great opportunity as an engineering student to carry out a project with science students. This lets me know how an engineer helping the project and put the idea into real products. I am also responsible for some art work in this team.
  
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<p>First, the inner membrane of the bacteria swells outwards for <b>vesicle invaginations</b>. The following step is to <b>sort magnetosome proteins to the mangetosome membrane (MM)</b> to perform specific functions in the transport and accumulation of iron.</p>
 
  
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<p>After protein sorting to the MM, the next step is iron uptake.
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The need to import iron for magnetite production makes MTB differs from other bio-mineralizers. Iron transporters in the MM 
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would pump Fe<sup>2+</sup>/Fe<sup>3+</sup> into the vesicle. </p>
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<p>Additionally, <i>MamM</i>, <i>MamB</i>, and <i>MamH</i> were suggested as additional iron transporters for magnetite biomineralization. As the concentration of iron ions increases inside the vesicle, biomineralization occurs [8]. </p>
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Policy and Practice Team: Carol</h3>
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Hello! I’m Carol, year 2 molecular biotechnology student. I’ve always been interested in biology, art and poetry. It’s my pleasure to join iGEM this year to learn different new things in an interesting way with a great team of people!
  
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<p>The process of magnetite biomineralization is tightly regulated through specific conditions such as: pH and the concentration of iron within the vesicle. It was also shown that such formation only occurs below a threshold value of 10 mbar of atmospheric pressure, and is inhibited at higher oxygen concentrations. <b>In other words, the size of particles is limited by atmospheric pressure and oxygen concentration.</b> It is found that at 0.25 mbar, magnetite biomineralization can produce particles up to 42 nm. As the condition rise to 10 mbar, the particle size dropped to about 20 nm. [9]  As the biomineralization of the magnetosome is reported to be highly affected by oxygen, we propose an educated guess that <b>magnetosome will have a higher probability to be successfully formed in our bacteria <i>Azotobacter</i></b> rather than <i>E. coli</i> due to its <b>intracellular microaerobic</b> characteristic. </p>
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Policy and Practice Team: Connie</h3>
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Hi. I'm Connie. A year 2 food and nutritional sciences student. I'm glad to be a member of iGEM team because I can explore and learn a lot in this event.
  
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<h2>References</h2>
 
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1. BAZYLINSKI, Dennis A.; FRANKEL, Richard B. Magnetosome formation in prokaryotes. <i>Nature Reviews Microbiology</i>, 2004, 2.3: 217-230.
 
 
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2. NUDELMAN, Hila; ZARIVACH, Raz. Structure prediction of magnetosome-associated proteins. <i>Frontiers in microbiology</i>, 2014, 5.
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Instructor: Asa</h3>
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I participated in iGEM a few years ago. It was my first experience of research and directed me to pursue postgraduate study. Now I am working in the field of structural biology.
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3. BLAKEMORE, Richard. Magnetotactic bacteria. <i>Science</i>, 1975, 190.4212: 377-379.
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Instructor: Cynthia </h3>
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Hi, this is Cynthia! I’m a Ph.D student in Food and Nutritional Sciences. This is my first time joining CUHK iGem team as an instructor. It has been an amazing journey working with aspiring and passionate team members who have been dedicated themselves in overcoming challenges and carried out innovative ideals. Hope to see intriguing ideals in Giant Jamboree~
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4. FRANKEL, Richard B.; BAZYLINSKI, Dennis A. Magnetosomes and magneto-aerotaxis. 2009.
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Instructor:  Jane </h3>
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Hi, I’m Jane. I’m a final year PhD student in School of Life Sciences in CUHK, with research focus on endocrine effects of environmental pollutants in fish. I’m so glad to work together with the iGEM team this year. All iGEMers are full of energy and fantastic! Can’t wait to see the final competition where all awesome ideas, including our “Magneto-bacter vinelandii”, are exchanged and direct to more exciting further applications!
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5. YAN, Lei, et al. Magnetotactic bacteria, magnetosomes and their application. <i>Microbiological research</i>, 2012, 167.9: 507-519.
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Instructor: Jacky </h3>
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Jacky is a final year PhD student in School of Life Science at CUHK. His research focus is aptamer technology and its integration on bio-sensors development for downstream applications. He also studies the mechanism of multi-drug resistant cancer, focusing on the organelle-specific targeted drug action.
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6. MAIER, R. J.; MOSHIRI, F. Role of the <i>Azotobacter vinelandii</i> nitrogenase-protective shethna protein in preventing oxygen-mediated cell death. <i>Journal of bacteriology</i>, 2000, 182.13: 3854-3857.
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Instructor: Leo</h3>
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Hello everyone, I am Leo Seak, a Macau student studying cell and molecular biology in CUHK. I was in the team of 2014 and becoming student instructor this year. I love anything unknown in this world. I think iGEM is exciting that you can explore synthetic biology and I cannot wait to see what iGemers have done this year in Giant Jamboree!
 
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7. LOHßE, Anna, et al. Functional analysis of the magnetosome island in <i>Magnetospirillum gryphiswaldense</i>: the <i>mamAB</i> operon is sufficient for magnetite biomineralization. <i>PLoS One</i>, 2011, 6.10: e25561.
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    <img src = "https://static.igem.org/mediawiki/2015/3/3b/CUHK_Instructor_Stephen.jpg" height ="300px" align="left" style="margin:0px 20px 0px 0px"><h3>
 +
Instructor: Stephen</h3>
 +
Hi! I'm Stephen, currently a graduate student focusing on plant cell biology research. Apart from having a taste of synthetic biology, which constantly surprises me with fascinating ideas, I'm honoured to guide a team of enthusiastic students with great perseverance. I hope the team can enjoy themselves and I'm looking forward to seeing other new ideas in the coming competition!
 +
 
 
</p>
 
</p>
−
<p>
+
    </td>
−
8. LOHßE, Anna, et al. Genetic dissection of the <i>mamAB</i> and <i>mms6</i> operons reveals a gene set essential for magnetosome biogenesis in <i>Magnetospirillum gryphiswaldense</i>. <i>Journal of bacteriology</i>, 2014, 196.14: 2658-2669.
+
</tr>
 +
 
 +
<tr>
 +
    </td>
 +
<td style ="border: 0px">
 +
    <p>
 +
    <img src = "https://static.igem.org/mediawiki/2015/4/49/CUHK_Prof_KM_Chan.jpeg" height ="300px" align="right" style="margin:0px 0px 0px 20px"><h3>
 +
Professor KM Chan</h3>
 +
Dr. King Ming Chan is an Associate Professor of School of Life Sciences and Director of Environmental Science Program, Faculty of Science, Chinese University. His research focuses on Aquatic Toxicology and Molecular Endocrinology using fish models.  Dr. Chan also studies the regulation of eukaryotic gene expression and transcription, focusing on understanding how metal-regulatory-element-binding transcription factors (MTFs) control metallothionein genes and how Pit-1s control pituitary polypeptide hormone genes.
 +
 
 
</p>
 
</p>
−
<p>
+
    </td>
−
9. ODENBACH, Stefan (ed.). Colloidal Magnetic Fluids: Basics, Development and Application of Ferrofluids. <i>Springer</i>, 2009.
+
</tr>
 +
 
 +
<tr>
 +
    </td>
 +
<td style ="border: 0px">
 +
    <p>
 +
    <img src = "https://static.igem.org/mediawiki/2015/6/61/CUHK_Prof_TF_Chan.jpeg" height ="300px" align="left" style="margin:0px 20px 0px 0px"><h3>
 +
Professor TF Chan </h3>
 +
Dr. Ting-Fung Chan is an Assistant Professor in the School of Life Sciences, and the Deputy Director of the Centre for Microbial Genomics and Proteomics at the Chinese University of Hong Kong. He is the Coordinator of the CUHK iGEM team. His researches mainly focus on genomics and bioinformatics of microbial pathogens and complex human phenotypes. He enjoys talking about science, but even more so for toys: Mindstorms NXT, RX-178, 5D Mk-II, LX200-ACF, YAS-875EX, and iGEM. He wishes his students would comprehend the fun and excitement of all aforementioned, but if that is not possible then at the very least, iGEM.
 +
 
 +
 
 
</p>
 
</p>
 +
    </td>
 +
</tr>
 +
 +
<tr>
 +
    </td>
 +
<td style ="border: 0px">
 +
    <p>
 +
    <img src = "https://static.igem.org/mediawiki/2015/a/a3/CUHK_Prof_SK_Kong.jpg" height ="300px" align="right" style="margin:0px 0px 0px 20px"><h3>
 +
Professor SK Kong </h3>
 +
Prof. Kong's laboratory studies the process of apoptosis. In particular, he is interested in elucidating how mitochondria regulate the apoptosis in 'normal' and drug-resistant cancer cells. He wonders how the resistance of mitochondria to MMP can explain the resistance of cancer cells to apoptosis induction, and he hopes to develop strategies for overcoming chemotherapy resistance by targeting tumor mitochondria. He believes that pharmacological interventions on mitochondria are good strategies to promote cell death in tumor cells. This research topic on apoptosis is therefore relevant to disease treatment with socioeconomic impacts.
 +
 +
 +
 +
</p>
 +
    </td>
 +
</tr>
 +
</table></center>
 +
 +
 +
<div class="member">
 +
 
</div></center>
 
</div></center>
 +
 +
 +
 +
<!-- from iGEM
 +
<h4>Inspiration</h4>
 +
<p>You can look at what other teams did to get some inspiration! <br />
 +
Here are a few examples:</p>
 +
<ul>
 +
<li><a href="https://2014.igem.org/Team:METU_Turkey_team">METU Turkey </a></li>
 +
<li><a href="https://2014.igem.org/Team:Colombia/Members">Colombia</a></li>
 +
<li><a href="https://2014.igem.org/Team:Stony_Brook/Team">Stony Brook</a></li>
 +
<li><a href="https://2014.igem.org/Team:OUC-China/Team">OUC-China</a></li>
 +
</ul>
 +
 +
<h5>What should this page contain?</h5>
 +
<ul>
 +
<li> Include pictures of your teammates, don’t forget instructors and advisors! </li>
 +
<li>You can add a small biography or a few words from each team member, to tell us what you like, and what motivated you to participate in iGEM.</li>
 +
<li>Take team pictures! Show us your school, your lab and little bit of your city.</li>
 +
<li>Remember that image galleries can help you showcase many pictures while saving space.</li>
 +
</ul>
 +
 +
-->
 +
</div>
 
</html>
 
</html>

Revision as of 19:16, 18 September 2015

Members United:

Team Captain: Louis

Hi!I am Louis, a year two biochemistry student in The Chinese University of Hong Kong (CUHK) and team leader this year. Welcome to our wiki page and hope our project interest you. If you have questions about our project or just want to chat with us :P, feel free to contact us. See you in the Great Jamboree.

Vice Team Captain: Sharon

Hey there! I am Sharon, a year 3 undergraduate student majoring in Biochemistry. Participating in IGEM has been very exciting, and I am looking forward to meeting other teams from all over the world!!!

Vice Team Captain: Alex

Hi, I am Alex, a year 2 biomedical engineering student. I am keen on lab and I believe that DNA, such a small thing can change the world. Thankfully I can see the world through the IGEM competition.

Secretary: Gigi

Hi everyone, I am Gigi, a year 2 biochemistry teenager. Igem is such an exciting platform for one to generate and execute any creative ideas. Not only can I apply what I have learnt in lectures but also i can learn a lot through own exploration and through team buddies from many other disciplines. This is so cool ~♡

Treasurer: Henry

Second year student studying molecular biotechnology.

I participate in iGEM 2015 as I am interested in synthetic biology and it also provides an opportunity to meet people from all over the world during the competition.

Wet Lab Team: Alyssa

Hi, I am Alyssa, a year three biochemistry student. I am glad to join IGEM2015. Teammates, knowledge are the precious things I have gained from IGEM. Work hard, play harder!

Wet Lab Team: Emily

Hello! I’m Emily, a year 2 Biomedical Engineering student. The reason for me to join iGEM is to gain the experience of doing lab, because I am an engineering student which means I don’t have a lot of chances to do life science labs. I also learnt to cooperate with a team of members with different personalities. It's a unique experience!

Wet Lab Team: Jimmy

Hi, I am Jimmy, a year2 science student form biochemistry major. I have chosen to join iGem team because I want to learn some techniques in doing experiment and learn how to work with others.

Wiki and Modeling Team: Peter

Hi, everyone! I am Peter, year 2 student studying biomedical engineering. I am so passionate about genetic engineering and feel excited in participating iGEM 2015. It is a great opportunity for me to meet people from all over the world. It also leads me to explore new frontiers and gain perfect experience in different biological perspective.

Wiki and Modeling Team: Angel

Hello! I am a Year-3 Engineering student. I enjoy making new friends and working with my team members. I want to learn more and do research in the lab. I also want to make more friends from other countries. Therefore, I join the iGEM team and the experience is great.

Design Team: Matthew

Hi! I am so excited to participate in iGEM 2015 CUHK team. It is definitely a great opportunity as an engineering student to carry out a project with science students. This lets me know how an engineer helping the project and put the idea into real products. I am also responsible for some art work in this team.

Policy and Practice Team: Carol

Hello! I’m Carol, year 2 molecular biotechnology student. I’ve always been interested in biology, art and poetry. It’s my pleasure to join iGEM this year to learn different new things in an interesting way with a great team of people!

Policy and Practice Team: Connie

Hi. I'm Connie. A year 2 food and nutritional sciences student. I'm glad to be a member of iGEM team because I can explore and learn a lot in this event.

Instructor: Asa

I participated in iGEM a few years ago. It was my first experience of research and directed me to pursue postgraduate study. Now I am working in the field of structural biology.

Instructor: Cynthia

Hi, this is Cynthia! I’m a Ph.D student in Food and Nutritional Sciences. This is my first time joining CUHK iGem team as an instructor. It has been an amazing journey working with aspiring and passionate team members who have been dedicated themselves in overcoming challenges and carried out innovative ideals. Hope to see intriguing ideals in Giant Jamboree~

Instructor: Jane

Hi, I’m Jane. I’m a final year PhD student in School of Life Sciences in CUHK, with research focus on endocrine effects of environmental pollutants in fish. I’m so glad to work together with the iGEM team this year. All iGEMers are full of energy and fantastic! Can’t wait to see the final competition where all awesome ideas, including our “Magneto-bacter vinelandii”, are exchanged and direct to more exciting further applications!

Instructor: Jacky

Jacky is a final year PhD student in School of Life Science at CUHK. His research focus is aptamer technology and its integration on bio-sensors development for downstream applications. He also studies the mechanism of multi-drug resistant cancer, focusing on the organelle-specific targeted drug action.

Instructor: Leo

Hello everyone, I am Leo Seak, a Macau student studying cell and molecular biology in CUHK. I was in the team of 2014 and becoming student instructor this year. I love anything unknown in this world. I think iGEM is exciting that you can explore synthetic biology and I cannot wait to see what iGemers have done this year in Giant Jamboree!

Instructor: Stephen

Hi! I'm Stephen, currently a graduate student focusing on plant cell biology research. Apart from having a taste of synthetic biology, which constantly surprises me with fascinating ideas, I'm honoured to guide a team of enthusiastic students with great perseverance. I hope the team can enjoy themselves and I'm looking forward to seeing other new ideas in the coming competition!

Professor KM Chan

Dr. King Ming Chan is an Associate Professor of School of Life Sciences and Director of Environmental Science Program, Faculty of Science, Chinese University. His research focuses on Aquatic Toxicology and Molecular Endocrinology using fish models. Dr. Chan also studies the regulation of eukaryotic gene expression and transcription, focusing on understanding how metal-regulatory-element-binding transcription factors (MTFs) control metallothionein genes and how Pit-1s control pituitary polypeptide hormone genes.

Professor TF Chan

Dr. Ting-Fung Chan is an Assistant Professor in the School of Life Sciences, and the Deputy Director of the Centre for Microbial Genomics and Proteomics at the Chinese University of Hong Kong. He is the Coordinator of the CUHK iGEM team. His researches mainly focus on genomics and bioinformatics of microbial pathogens and complex human phenotypes. He enjoys talking about science, but even more so for toys: Mindstorms NXT, RX-178, 5D Mk-II, LX200-ACF, YAS-875EX, and iGEM. He wishes his students would comprehend the fun and excitement of all aforementioned, but if that is not possible then at the very least, iGEM.

Professor SK Kong

Prof. Kong's laboratory studies the process of apoptosis. In particular, he is interested in elucidating how mitochondria regulate the apoptosis in 'normal' and drug-resistant cancer cells. He wonders how the resistance of mitochondria to MMP can explain the resistance of cancer cells to apoptosis induction, and he hopes to develop strategies for overcoming chemotherapy resistance by targeting tumor mitochondria. He believes that pharmacological interventions on mitochondria are good strategies to promote cell death in tumor cells. This research topic on apoptosis is therefore relevant to disease treatment with socioeconomic impacts.