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Revision as of 02:12, 19 September 2015
Project Description
Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the world's most serious public health problems. Although tuberculosis is curable and the treatment success rate is high, it is still the second most common cause of death from infectious disease (after HIV). It caused more than 1.3 million deaths annually, and most of the deaths occur in developing countries that are lack of effective identification of those in need of therapy, with an enormous amount of delayed or failed diagnosis.
Case detection is currently the rate-limiting step in disease control. The available Nucleic Acid Detection (NAD) Method is sensitive and fast, but does not reach the requirement of specificity and reliability.
To obviate such problems, Peking iGEM team is developing a novel PC Reporters system that can transform biomarkers of the disease into optical signal. Combined with array design and statistical analysis, the presence of Mycobacterium tuberculosis can be easily verified. It can also be easily used in developing areas with designed hardware development. We believe this new advanced system can turn out as a powerful tool in disease diagnosis, with high specificity and reliability.
POSTER 97 - Zoon 4 - Hall C
PRESENTATION Saturday - Room 302 - 11:30 AM
Thanks for your attention!
Specificity
Designed the novel Paired dCas9 (PC) Reporter system to improve the specificty and tested on real TB genome.
Reliability
Combine array design and statistical analysis to verify the presence of Mycobacterium tuberculosis.
Portability
Designed a cheap and portable prototype to be used in developing regions.
Bench to Bedside
Come from bedside to bench, and back to bedside again.