Difference between revisions of "Team:SVCE Chennai"
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<h2> PROJECT DESCRIPTION </h2> | <h2> PROJECT DESCRIPTION </h2> | ||
<p> Minicells are achromosomal cells formed by aberrant cell division in living cells. Several mutant strains have been isolated that have been shown to harbor a mutation in a particular set of genes. FtsZ, one of the proteins involved in cell division has been shown to be one of those. Overexpression of this protein leads to septation at the poles, leading to the formation of the so-called minicells. The non-replicative behaviour of the minicells gives rise to a broad spectrum of applications. Our project focusses on engineering minicells to produce certain novel peptides that can have a wide range of applications in fields like animal husbandry, human probiotics and strain selection. Probiotic minicells will be engineered to produce Bacillocin 1580, a bacteriocin that specifically targets Campylobacter jejuni, the causative organism for Campylobacteriosis in humans that spreads through contaminated poultry. Clostridium botulinum – specific bacteriocin producing minicells can also be engineered to prevent botulism through packaged foods. One of the most common issues in the field of Medicine and in general, Biology, the formation of MRSA biofilms, can also be addressed with this novel approach. </p> | <p> Minicells are achromosomal cells formed by aberrant cell division in living cells. Several mutant strains have been isolated that have been shown to harbor a mutation in a particular set of genes. FtsZ, one of the proteins involved in cell division has been shown to be one of those. Overexpression of this protein leads to septation at the poles, leading to the formation of the so-called minicells. The non-replicative behaviour of the minicells gives rise to a broad spectrum of applications. Our project focusses on engineering minicells to produce certain novel peptides that can have a wide range of applications in fields like animal husbandry, human probiotics and strain selection. Probiotic minicells will be engineered to produce Bacillocin 1580, a bacteriocin that specifically targets Campylobacter jejuni, the causative organism for Campylobacteriosis in humans that spreads through contaminated poultry. Clostridium botulinum – specific bacteriocin producing minicells can also be engineered to prevent botulism through packaged foods. One of the most common issues in the field of Medicine and in general, Biology, the formation of MRSA biofilms, can also be addressed with this novel approach. </p> | ||
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<h4>Before you start: </h4> | <h4>Before you start: </h4> | ||
Revision as of 17:26, 15 July 2015
Welcome to SVCE iGEM 2015!
PROJECT DESCRIPTION
Minicells are achromosomal cells formed by aberrant cell division in living cells. Several mutant strains have been isolated that have been shown to harbor a mutation in a particular set of genes. FtsZ, one of the proteins involved in cell division has been shown to be one of those. Overexpression of this protein leads to septation at the poles, leading to the formation of the so-called minicells. The non-replicative behaviour of the minicells gives rise to a broad spectrum of applications. Our project focusses on engineering minicells to produce certain novel peptides that can have a wide range of applications in fields like animal husbandry, human probiotics and strain selection. Probiotic minicells will be engineered to produce Bacillocin 1580, a bacteriocin that specifically targets Campylobacter jejuni, the causative organism for Campylobacteriosis in humans that spreads through contaminated poultry. Clostridium botulinum – specific bacteriocin producing minicells can also be engineered to prevent botulism through packaged foods. One of the most common issues in the field of Medicine and in general, Biology, the formation of MRSA biofilms, can also be addressed with this novel approach.
Before you start:
Please read the following pages:
Styling your wiki
You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.
While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.
Editing your wiki
On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world!
See tips on how to edit your wiki on the Template Documentation page.
Templates
This year we have created templates for teams to use freely. More information on how to use and edit the templates can be found on the Template Documentation page.
Tips
This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started:
- State your accomplishments! Tell people what you have achieved from the start.
- Be clear about what you are doing and how you plan to do this.
- You have a global audience! Consider the different backgrounds that your users come from.
- Make sure information is easy to find; nothing should be more than 3 clicks away.
- Avoid using very small fonts and low contrast colors; information should be easy to read.
- Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the iGEM 2015 calendar
- Have lots of fun!
Inspiration
You can also view other team wikis for inspiration! Here are some examples:
- 2014 SDU Denmark
- 2014 Aalto-Helsinki
- 2014 LMU-Munich
- 2014 Michigan
- 2014 ITESM-Guadalajara
- 2014 SCU-China
Uploading pictures and files
You can upload your pictures and files to the iGEM 2015 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name.
When you upload, set the "Destination Filename" to Team:YourOfficialTeamName/NameOfFile.jpg. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)