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| <p> <h2> Mind the Gut: Abstract</h2></p> | | <p> <h2> Mind the Gut: Abstract</h2></p> |
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− | The gut–brain axis refers to the biochemical signalling taking place between the gastrointestinal tract and the nervous system, often involving intestinal microbiota, which have been shown to play an important role in healthy brain function. The current research suggests that gut microbes secrete neuroactive compounds – including neurotransmitters – that interact with the brain via two main mechanisms: the vagus nerve, connecting brain and digestive tract, and the immune system, which maintains its own means of communication with the brain.</p>
| + | Current research suggests that gut microbes secrete neuroactive compounds that act on the gut-brain axis and play an important role in healthy brain function. The UCL iGEM team has developed novel synthetic psychobiotics that mimic these neuromodulatory strategies identified in endogenous intestinal strains. |
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− | In line with the ongoing research, UCL iGEM 2015 aims to develop synthetic probiotic strains that mimic the neuromodulatory strategies identified in gut microbes, with a focus on regulation of tryptophan pathway and signalling via serotonin. Additionally, in order to incorporate our neuromodulators into precise and safe therapeutic devices, we are developing a set of sensors capable of detecting mood-related physiological changes in the gut environment. </p>
| + | We have designed safe therapeutic devices that target metabolic pathways for neurochemical biosynthesis. Additionally, we have assessed biocontainment and integrated a sensor detecting mood-related physiological changes in the gut environment. </p> |
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− | Available small molecule treatments are associated with both stigma and side effects. We believe that, besides aiding in better understanding of the communication between the gut microbiome and nervous system, our work will also lay a foundation for novel user-friendly treatments targeting a range of mental health disorders. </p>
| + | In any year, mental health conditions affect one in four of us and available small molecule treatments have associated stigma and side effects. We believe that, besides aiding in the better understanding of the communication between gut microbiota and brain, our work will also lay a foundation for novel user-friendly treatments for mental health conditions.</p> |
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