Team:ETH Zurich/Modeling/Reaction-diffusion
Full Model
3D model in COMSOL with reaction-diffusion
Four cases
Assumptions
- Target mammalian cell located in the center of the well
- Constant rate of lactate production
- E. coli bound to target cell abstracted into homogeneous layer around target cell
- Two different forms of unbound E. coli
- Discrete: single cell of E. coli suspended in the medium
- Bulk: reactions of the rest of the E. coli simulated in same space as medium
- Lactate represented as two states: inside and outside E. coli, denoted \(Lac_{int}\) and \(Lac_{ext}\), respectively
- \(Lac_{int}\) can diffuse freely through medium and membranes, \(Lac_{ext}\) cannot
- Use to simulate different import and export rates of lactate into E. coli
- Bulk E. coli grow logistically
Results
1D model in MATLAB
1D and 2D COMSOL models
