"What I cannot create I do not understand." - Richard Feynmann
References
Description
Aguilera, L., Campos, E., Giménez, R., Badía, J., Aguilar, J., & Baldoma, L. (2008). Dual role of LldR in regulation of the lldPRD operon, involved in L-lactate metabolism in Escherichia coli. Journal of bacteriology, 190(8), 2997-3005.
Chen, Z., Lu, W., Garcia-Prieto, C., & Huang, P. (2007). The Warburg effect and its cancer therapeutic implications. Journal of bioenergetics and biomembranes, 39(3), 267-274.
Cooke, T., Reeves, J., Lanigan, A., & Stanton, P. (2001). HER2 as a prognostic and predictive marker for breast cancer. Annals of oncology, 12(suppl 1), S23-S28.
Cooperberg, M. R., Broering, J. M., & Carroll, P. R. (2009). Risk assessment for prostate cancer metastasis and mortality at the time of diagnosis. Journal of the National Cancer Institute, 101(12), 878-887.
van Engeland, M., Nieland, L. J., Ramaekers, F. C., Schutte, B., & Reutelingsperger, C. P. (1998). Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry,31(1), 1-9.
Garcea, G., Neal, C. P., Pattenden, C. J., Steward, W. P., & Berry, D. P. (2005). Molecular prognostic markers in pancreatic cancer: a systematic review. European Journal of Cancer, 41(15), 2213-2236.
Goentoro, L., Shoval, O., Kirschner, M. W., & Alon, U. (2009). The incoherent feedforward loop can provide fold-change detection in gene regulation. Molecular cell, 36(5), 894-899.
Hawkins, T. E., Das, D., Young, B., & Moss, S. E. (2002). DT40 cells lacking the Ca2+-binding protein annexin 5 are resistant to Ca2+-dependent apoptosis. Proceedings of the National Academy of Sciences, 99(12), 8054-8059.
International Agency for Research on Cancer. (2014). World cancer report 2014. Geneva: WHO.
Singhal, S., Vachani, A., Antin-Ozerkis, D., Kaiser, L. R., & Albelda, S. M. (2005). Prognostic implications of cell cycle, apoptosis, and angiogenesis biomarkers in non–small cell lung cancer: a review. Clinical Cancer Research,11(11), 3974-3986.
Sleijfer, S., Gratama, J. W., Sieuwerts, A. M., Kraan, J., Martens, J. W., & Foekens, J. A. (2007). Circulating tumour cell detection on its way to routine diagnostic implementation?. European Journal of Cancer, 43(18), 2645-2650.
Srivastava, R. K. (2001). TRAIL/Apo-2L: mechanisms and clinical applications in cancer. Neoplasia, 3(6), 535-546.
Saxe, Charles. Unlocking the misteries of metastasis. American Cancer Society. 23 January 2013
Glossary
Cáceres, G, Puskas, J. Circulating Tumor Cells: A Window Into Tumor Development
and Therapeutic Effectiveness. Cancer control Vol. 22, No. 2 (2015)
Kalluri, R., & Weinberg, R. A. (2009). The basics of epithelial-mesenchymal transition. The Journal of clinical investigation, 119(6), 1420.
Miller, M. B., & Bassler, B. L. (2001). Quorum sensing in bacteria. Annual Reviews in Microbiology, 55(1), 165-199.
Núñez, M. F., Kwon, O., Wilson, T. H., Aguilar, J., Baldoma, L., & Lin, E. C. (2002). Transport of L-lactate, D-lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli. Biochemical and biophysical research communications, 290(2), 824-829.
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009). Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science, 324(5930), 1029-1033.
Johnstone, R. W. et al. The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nature Reviews Cancer 8, 782-798 (2008)
Experimental
de Bruyne, M. et al. Cancer Letters Volume 332, Issue 2, (2013), Pages 175–183
Chiu, T.-K. et al. Development of a Microfluidic-Based Optical Sensing Device for Label-Free Detection of Circulating Tumor Cells (CTCs) Through Their Lactic Acid Metabolism. Sensors (Basel) 15, 6789–6806 (2015).
Vander Heiden, M.G. et al. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. Science 22 Vol. 324 no. 5930 pp. 1029-1033 (2009)
Zhang, L. & Fang. Mechanisms of resistance to TRAIL-induced apoptosis in cancer. Cancer Gene Therapy 12, 228–237 (2005)
Thomas, W. D & Hersey, P. (1998) TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Apoptosis in Fas Ligand-Resistant Melanoma Cells and Mediates CD4 T Cell Killing of Target Cells. The Journal of Immunology vol. 161 no. 5 2195-2200
Modeling
Subhayu Basu, Yoram Gerchman, Cynthia H. Collins, Frances H. Arnold, and Ron Weiss. A synthetic
multicellular system for programmed pattern formation. Nature, 434(7037):1130–1134, April 2005.
Fatin-Rouge, N., Starchev, K., & Buffle, J. (2004). Size effects on diffusion processes within agarose gels. Biophysical Journal, 86(5), 2710-2719.
Stewart, P. S. (2003). Diffusion in biofilms. Journal of bacteriology, 185(5), 1485-1491.
Trovato, A., Seno, F., Zanardo, M., Alberghini, S., Tondello, A., & Squartini, A. (2014). Quorum vs. diffusion sensing: a quantitative analysis of the relevance of absorbing or reflecting boundaries. FEMS microbiology letters, 352(2), 198-203.
Lian-Hui Wang, Li-Xing Weng, Yi-Hu Dong, and Lian-Hui Zhang. Specificity and Enzyme Kinetics of
the Quorum-quenching N-Acyl Homoserine Lactone Lactonase (AHL-lactonase). Journal of Biological
Chemistry, 279(14):13645–13651, April 2004.
Marc Weber and Javier Buceta. Dynamics of the quorum sensing switch: stochastic and non-stationary effects.BMC Systems Biology, 7(1):6, January 2013.
