Team:Harvard BioDesign

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Welcome to the Harvard BioDesign 2015 wiki!

The "official" place where flocculation happens and llamas are appreciated.

About our project

Our team is engineering E. coli to bind to colon cancer cells through the use of their type I pili, which are hair-like appendages that have an adhesive domain. Naturally, the strains in E. coli that produce pili bind to alpha-D-mannose, which can cause urinary tract infections. However, our team is altering a non-harmful strain to produce pili using a modified Fim gene in order to localize the bacteria as a tool. For treatment of cancer, once the bacteria are localized on the cells, the next step is to make them capable of producing a concentrated toxin or to administer a therapeutic. Other potential applications for our E. coli include water pollution clean up through methods such as flocculation and targeting areas through GFP.

How to navigate our site

Here is an easy guide to finding information on our wiki site. On the top of every page you will see a flask. When you click on it, it will open up the main navigation menu. The top section includes links of the different sections on the current page. The lower links are to switch to a new page. You can see all the pages by looking at our site map listed below.

Click Here to see our site map