Difference between revisions of "Team:BGU Israel"

 
(33 intermediate revisions by 3 users not shown)
Line 2: Line 2:
  
 
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en" dir="ltr">
 
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en" dir="ltr">
−
 
−
    <head>
 
  
−
<!-- Scripts -->
+
  <head>
−
<script src="http://igembgu.com/wiki/JS/TUM13_jquery-1.10.2.js?action=raw&amp;ctype=text/javascript" type="text/javascript"></script>
+
−
<script src="http://igembgu.com/wiki/JS/TUM13_slimbox2.js?action=raw&amp;ctype=text/javascript" type="text/javascript"></script>
+
−
<script src="http://igembgu.com/wiki/JS/TUM13_bxslider.js?action=raw&amp;ctype=text/javascript" type="text/javascript"></script>
+
−
<script src="http://igembgu.com/wiki/JS/TUM13_Script?action=raw&amp;ctype=text/javascript" type="text/javascript"></script>
+
−
<script src="http://igembgu.com/wiki/JS/TUM13_history.js?action=raw&amp;ctype=text/javascript" type="text/javascript"></script>
+
  
−
<!-- Stylesheets -->
+
    <!-- Scripts -->
−
<link href="http://igembgu.com/wiki/css/TUM13_normalize.css" type="text/css" rel="stylesheet">
+
    <script type="text/javascript"  
−
<link href="http://igembgu.com/wiki/css/UM13_reset.css" type="text/css" rel="stylesheet">
+
            src="https://2015.igem.org/Template:BGU_Israel/js/TUM13_jquery-1.10.2?action=raw&ctype=text/javascript">
−
<link href="http://igembgu.com/wiki/css/TUM13_slimbox2.css" type="text/css" rel="stylesheet">
+
    </script>
−
<link href="http://igembgu.com/wiki/css/TUM13_normalize.css" type="text/css" rel="stylesheet">
+
    <script type="text/javascript"  
−
<link href="http://igembgu.com/wiki/css/TUM13_bxslider.css" type="text/css" rel="stylesheet">
+
            src="https://2015.igem.org/Template:BGU_Israel/js/TUM13_slimbox2?action=raw&ctype=text/javascript">
−
<link href="http://igembgu.com/wiki/css/TUM13_wiki.css" type="text/css" rel="stylesheet">
+
    </script>
−
</head>
+
     <script type="text/javascript"  
−
   
+
             src="https://2015.igem.org/Template:BGU_Israel/js/TUM13_bxslider?action=raw&ctype=text/javascript">
−
   
+
    </script>
−
    <body class="mediawiki  ltr ns-0 ns-subject page-Team_BGU_Israel">   
+
     <script type="text/javascript"  
−
      <div id="content">
+
            src="https://2015.igem.org/Template:BGU_Israel/js/TUM13_Script?action=raw&ctype=text/javascript">
−
         
+
    </script>
−
        <img src="https://static.igem.org/mediawiki/2015/8/8f/2015igembanner.jpg" height="150px" width="100%">
+
    <script type="text/javascript"  
−
<a name="top" id="top"></a>
+
            src="https://2015.igem.org/Template:BGU_Israel/js/TUM13_history?action=raw&ctype=text/javascript">
−
<h1 class="firstHeading">Team:BGU Israel</h1>
+
     </script>
−
<div id="bodyContent">
+
−
+
−
<div id="contentSub"></div>
+
−
<!-- start content -->
+
−
<p>
+
−
<div id="header-container">
+
−
   
+
−
     <div id="header">
+
−
        <table style="background-color:transparent ">
+
−
             <tr>
+
−
                <td style="width:200px"></td>
+
−
                <td> <img src="https://static.igem.org/mediawiki/2015/8/83/Igem_bgu_logo.png" height="120px" width="490px"><td>
+
−
                                                                                                                        <td></td>
+
−
                                                                                                                   
+
−
            </tr>
+
−
        </table>
+
−
    </div>
+
−
     <!--
+
−
        <a href="https://2015.igem.org/Main_Page"><img id="igem-logo" src="https://static.igem.org/mediawiki/2013/9/9c/TUM13_igem-logo.png" /></a>
+
−
        <a href="http://www.tum.de/en/homepage/"><img id="tum-logo" src="https://static.igem.org/mediawiki/2013/9/9b/TUM13_tum-logo.png" /></a>
+
−
        <a href="https://2013.igem.org/Team:TU-Munich"><img id="physco-logo" src="https://static.igem.org/mediawiki/2013/c/c4/TUM13_physco-logo-klein.png" /></a>
+
−
     </div>
+
  
−
  <!-- Start of menu -->
+
    <!-- Stylesheets -->
−
     <div id="menu">
+
     <link rel="stylesheet" type="text/css"
−
        <ul>
+
          href="https://2015.igem.org/Template:BGU_Israel/css/TUM13_normalize?action=raw&ctype=text/css" />
−
            <li><a id="home" href="https://2015.igem.org/Team:BGU_Israel">Home</a></li>
+
    <link rel="stylesheet" type="text/css"
−
            <li><a id="A2" href="https://2015.igem.org/Team:BGU_Israel/Team">Team</a>
+
          href="https://2015.igem.org/Template:BGU_Israel/css/UM13_reset?action=raw&ctype=text/css" />
−
              <!--  <ul> optional
+
    <link rel="stylesheet" type="text/css"
−
                    <li><a href="https://2013.igem.org/Team:BGU_Israel/Team/Members">Members</a></li>
+
          href="https://2015.igem.org/Template:BGU_Israel/css/TUM13_slimbox2?action=raw&ctype=text/css" />
−
                    <li><a href="https://2013.igem.org/Team:BGU_Israel/Team/Sponsors">Sponsors</a></li>
+
    <link rel="stylesheet" type="text/css"
−
                    <li><a href="https://2013.igem.org/Team:BGU_Israel/Team/Collaborations">Collaborations</a></li>
+
          href="https://2015.igem.org/Template:BGU_Israel/css/TUM13_normalize?action=raw&ctype=text/css" />
−
                    <li><a href="https://2013.igem.org/Team:BGU_Israel/Team/Gallery">Pictures</a></li>
+
    <link rel="stylesheet" type="text/css"
−
                    <li><a href="https://2013.igem.org/Team:BGU_Israel/Team/Statistics">Timeline</a></li>
+
          href="https://2015.igem.org/Template:BGU_Israel/css/TUM13_bxslider?action=raw&ctype=text/css" />
−
                    <li><a href="https://2013.igem.org/Team:BGU_Israel/Team/Attributions">Attributions</a></li>
+
    <link rel="stylesheet" type="text/css"
−
                    <li><a href="https://2013.igem.org/Team:BGU_Israel/Team/Judging">Judging</a></li>
+
          href="https://2015.igem.org/Template:BGU_Israel/css/TUM13_wiki?action=raw&ctype=text/css" />
−
                </ul> -->
+
    <link rel="stylesheet" type="text/css"
−
            </li>
+
          href="https://2015.igem.org/Template:BGU_Israel/css/BGU15_addition?action=raw&ctype=text/css" />
−
           
+
−
            <li>Project
+
−
                            <ul>
+
−
                                <li><a id="A1" href="https://2015.igem.org/Team:BGU_Israel/Description">Description</a></li>
+
−
                              <li> <a href="https://2015.igem.org/Team:BGU_Israel/Experiments">Experiments &amp; Protocols</a>  </li>
+
−
                                <li><a href="https://2015.igem.org/Team:BGU_IsraelResults">Results</></a>  </li>
+
−
                                <li><a href="https://2015.igem.org/Team:BGU_Israel/Design">Design</a></li>
+
−
                            </ul>
+
−
            </li>
+
  
−
         
+
</head>
−
            <li>Parts
+
</html>
−
            <ul>
+
{{BGU_Israel/menu}}
−
<li><a href="https://2015.igem.org/Team:BGU_Israel/Parts">Team Parts</a></li>
+
<html>
−
<li><a href="https://2015.igem.org/Team:BGU_Israel/Basic_Part">Basic Parts</a>  </li>
+
−
<li><a href="https://2015.igem.org/Team:BGU_Israel/Composite_Part">Composite Parts</a></li>
+
−
<li><a href="https://2015.igem.org/Team:BGU_Israel/Part_Collection">Part Collection</a> </li>
+
−
</ul>
+
−
</li>
+
  
−
<li><a id="A3" href="https://2015.igem.org/Team:BGU_Israel/Notebook">Notebook</a></li>
 
−
     
 
−
            <li> MORE
 
−
                <ul>
 
−
                    <li><a href="https://2015.igem.org/Team:BGU_Israel/Attributions">Attributions</a></li>
 
−
                  <li>  <a href="https://2015.igem.org/Team:BGU_Israel/Collaborations">Collaborations</a></li>
 
−
                  <li> <a href="https://2015.igem.org/Team:BGU_Israel/Practices">Human practices</a></li>
 
−
                  <li> <a href="https://2015.igem.org/Team:BGU_Israel/Safety">Safety</a></li>
 
−
                  <li> <a href="https://2015.igem.org/Team:BGU_Israel/Modeling">Modeling</a></li>
 
−
                  <!-- <li> <a href="https://2015.igem.org/Team:BGU_Israel/Measurement">MEASUREMENT</a></li>
 
−
<!-- <a href="https://2015.igem.org/Team:BGU_Israel/Software"><li>SOFTWARE</li></a> -->
 
−
                  <li> <a href="https://2015.igem.org/Team:BGU_Israel/Entrepreneurship">Entrepreneurship</a></li>
 
−
                   
 
−
                </ul>
 
−
            </li>
 
  
−
         
 
  
−
+
  <body class="mediawiki  ltr ns-0 ns-subject page-Team_BGU_Israel">
−
           
+
    <div id="Div1">
  
 +
            <div id="wikicontent-container">
 +
              <div id="wikicontent">
 +
                <br />
 +
                <br />
  
−
        </ul>
 
−
    </div>
 
−
    <!-- End of menu -->
 
  
−
</div>
+
<ul class="bxslider">  
−
 
+
−
 
+
−
 
+
−
 
+
−
</p><p><br />
+
−
</p>
+
−
<div id="wikicontent-container">
+
−
    <div id="wikicontent"><ul class="bxslider">  
+
 
                               <li><img src="https://static.igem.org/mediawiki/2015/2/26/BGU_home_slider_team1.jpg" /></li>
 
                               <li><img src="https://static.igem.org/mediawiki/2015/2/26/BGU_home_slider_team1.jpg" /></li>
 
                               <li><img src="https://static.igem.org/mediawiki/2015/a/a3/BGU_home_slider_team2.jpg" /></li>
 
                               <li><img src="https://static.igem.org/mediawiki/2015/a/a3/BGU_home_slider_team2.jpg" /></li>
Line 126: Line 60:
 
                               <li><img src="https://static.igem.org/mediawiki/2015/5/5c/BGU_home_slider_team4.jpg" /></li>
 
                               <li><img src="https://static.igem.org/mediawiki/2015/5/5c/BGU_home_slider_team4.jpg" /></li>
 
                               <li><img src="https://static.igem.org/mediawiki/2015/6/6a/BGU_home_slider_team5.jpg" /></li>
 
                               <li><img src="https://static.igem.org/mediawiki/2015/6/6a/BGU_home_slider_team5.jpg" /></li>
 +
                              <li><img src="https://static.igem.org/mediawiki/2015/b/b6/BGU_home_slider_team6.jpg" /></li>
 
                           </ul>
 
                           </ul>
 
          
 
          
Line 133: Line 68:
 
             <table style="width: 100%; border-style: hidden;" >
 
             <table style="width: 100%; border-style: hidden;" >
 
                 <tr style="border-style: hidden;">
 
                 <tr style="border-style: hidden;">
−
                    <td style="border-style: hidden;"><a href="https://2015.igem.org/Team:BGU_Israel/judging" class="rotate"><img src="https://static.igem.org/mediawiki/2015/1/17/BGU_home_icon_trophy.png" alt=""></a></td>
+
<td style="border-style: hidden;"><a href="https://2015.igem.org/Team:BGU_Israel/Achievements" ><div align="center"><img src="https://static.igem.org/mediawiki/2015/1/17/BGU_home_icon_trophy.png" alt=""></a></div></td>
−
                    <td style="border-style: hidden;"><a href="https://2015.igem.org/Team:BGU_Israel/Entrepreneurship" class="rotate"><img src="https://static.igem.org/mediawiki/2015/b/b9/BGU_home_icon_briefcase.png" alt=""></a></td>        
+
 
−
                    <td style="border-style: hidden;"><a href="https://2015.igem.org/Team:BGU_Israel/Practices" class="rotate"><img src="https://static.igem.org/mediawiki/2015/8/89/BGU_Rgb.png" alt=""></a></td>
+
<td style="border-style: hidden;"><a href="https://2015.igem.org/Team:BGU_Israel/Description"><div align="center"><img src="https://static.igem.org/mediawiki/2015/3/3d/Bgu_project.png" alt=""></a></div></td>
−
                    <td style="border-style: hidden;"><a href="https://2015.igem.org/Team:BGU_Israel/Practices" class="rotate"><img src="https://static.igem.org/mediawiki/2015/8/8f/Bgu_Education.png" alt=""></a></td>
+
 
−
                    <td style="border-style: hidden;"><a href="https://2015.igem.org/Team:BGU_Israel/Entrepreneurship" class="rotate"><img src="https://static.igem.org/mediawiki/2015/8/80/Camera.png" alt=""></a></td>
+
<td style="border-style: hidden;"><a href="https://2015.igem.org/Team:BGU_Israel/Design" ><div align="center"><img src="https://static.igem.org/mediawiki/2015/6/6b/Bgu_brush-pencil.png" alt=""></a></div></td>
−
                </tr>
+
 
−
                <tr style="border-style: hidden;">
+
<td style="border-style: hidden;"><a href="https://2015.igem.org/Team:BGU_IsraelResults"><div align="center"><img src="https://static.igem.org/mediawiki/2015/b/b0/Bgu_brightness.png" alt=""></a></div></td>
−
                     <td style="text-align: left; border-style: hidden;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Judging</td>
+
<!-- https://static.igem.org/mediawiki/2015/b/b9/BGU_home_icon_briefcase.png -->
−
                     <td style="text-align: left; border-style: hidden;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Entrepreneurship</td>
+
 
−
                     <td style="text-align: left; border-style: hidden;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Photos</td>Best Integrated Human Practices award
+
<td style="border-style: hidden;"><a href="https://2015.igem.org/Team:BGU_Israel/Practices" ><div align="center"><img src="https://static.igem.org/mediawiki/2015/8/89/BGU_Rgb.png" alt=""></a></div></td>
−
                     <td style="text-align: left; border-style: hidden;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Best Education and Public Outreach award</td>
+
 
−
                     <td style="text-align: left; border-style: hidden;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Photos</td>
+
 
−
                 
+
 
 +
              </tr>
 +
              <tr style="border-style: hidden;">
 +
                     <td style="text-align: left; border-style: hidden;"><div align="center">Achievements</div></td>
 +
                     <td style="text-align: left; border-style: hidden;"><div align="center">Project description</div></td>
 +
                     <td style="text-align: left; border-style: hidden;"><div align="center">Design</div></td>
 +
                     <td style="text-align: left; border-style: hidden;"><div align="center">Results</div></td>
 +
                     <td style="text-align: left; border-style: hidden;"><div align="center">Practices and Polices</div></td>
 
                      
 
                      
−
                </tr>
+
                 
 +
          </tr>
  
 
             </table>
 
             </table>
−
           
+
        </div>
−
       
+
<br />
  
−
<h2> <span class="mw-headline" id="PhyscoFilter_.E2.80.93_Clean_different."> Cancer &ndash; what is the problem? </span></h2>
+
<h2> <span class="mw-headline" id="PhyscoFilter_.E2.80.93_Clean_different."> The Boomerang system: synthetic machine for cancer therapy </span></h2>
−
        <p>Despite the huge investment in research and the development of a variety of treatment methods, cancer is still a major cause of death in the world.  
+
<p>Despite recent treatment advancements, cancer is still a major cause of mortality worldwide. One of the fundamental problems preventing the development of effective therapy is the difficulty to target cancer cells exclusively.  
−
            <br /> Today, both surgical and pharmacological treatments against most types of cancer are not accurate enough to identify and treat the disease on a cellular level.
+
  <br />In Boomerang, we're engineering a genetic device based on a simple concept of AND logic gate: the activation of our CRISPR/Cas9-based system is dependent on the existence of two cancer-specific promoters that control the expression of Cas9 and gRNA, and the combination of these two will occur only in cancer cells. CRISPR/Cas9 system allows several applications of Boomerang: 1) disruption of genes essential for cancer survival; and 2) activation of suicide genes, or color proteins for cancer cell detection (e.g., for complete surgical removal).  <br />Our system can be potentially designed according to unique characteristics of a patient's tumor, paving the way to personalized medicine. We hope that our strategy will change the approach to cancer treatments.</p>
−
            On the other hand, novel biological treatments being developed were only found effective for a relatively small number of patients.
+
     
−
            <br />In cancer, many cellular and molecular processes take place, enabling the tumor to develop and spread in the body.
+
−
            <br />We believe that it is possible to take advantage of the many typical biological mechanisms of cancer cells, by developing a synthetic biology-based system for identifying and treating cancer on a cellular level.
+
−
            Together as a team, we developed a modular system which identifies numerous genetic changes in cancer cells and responds by activating a synthetic machine that executes a cell suicide program or enables color-based "tagging" of the cells for tumor detection, ensuring complete surgical removal.</p>
+
−
       
+
 
          
 
          
 
         <br /><br />
 
         <br /><br />
Line 167: Line 106:
 
               <source src="https://static.igem.org/mediawiki/2015/6/65/IGEMbgu.mp4" type="video/mp4">
 
               <source src="https://static.igem.org/mediawiki/2015/6/65/IGEMbgu.mp4" type="video/mp4">
 
               </video>
 
               </video>
−
 
+
</p>
 
  <!-- movie -->
 
  <!-- movie -->
  
 
  <br /><br />
 
  <br /><br />
 +
  
  
Line 203: Line 143:
 
   <table>
 
   <table>
 
<tr>
 
<tr>
−
         <td><div class="checklist" >
+
         <td style="border-style: hidden;"><div class="checklist" >
 
           <div class="medal">
 
           <div class="medal">
−
               <a href="https://2015.igem.org/Team:BGU_Israel/Judging">
+
               <a href="https://2015.igem.org/Team:BGU_Israel/Achievements">
 
                 <img src="https://static.igem.org/mediawiki/2015/b/b7/Medalcheck.png" height="150px" width="600px" />
 
                 <img src="https://static.igem.org/mediawiki/2015/b/b7/Medalcheck.png" height="150px" width="600px" />
 
               </a>  
 
               </a>  
 
           </div></div></td>
 
           </div></div></td>
−
          <td>  
+
        </tr></table>
−
          <center style="margin-top: 10px;">
+
<br /><br />
−
          <div id="clustrmaps-widget"></div><script type="text/javascript">                                             var _clustrmaps = { 'url': 'https://2015.igem.org/Team:BGU_Israel', 'user': 1176746, 'server': '3', 'id': 'clustrmaps-widget', 'version': 1, 'date': '2015-08-19', 'lang': 'en', 'corners': 'square' }; (function () { var s = document.createElement('script'); s.type = 'text/javascript'; s.async = true; s.src = 'http://www3.clustrmaps.com/counter/map.js'; var x = document.getElementsByTagName('script')[0]; x.parentNode.insertBefore(s, x); })();</script><noscript><a href="http://www3.clustrmaps.com/user/9bc11f4aa"><img src="http://www3.clustrmaps.com/stats/maps-no_clusters/2015.igem.org-Team-BGU_Israel-thumb.jpg" alt="Locations of visitors to this page" /></a></noscript>
+
<!-- finish HERE ----------------------------------------------------------------------------------------------->
−
            </center>
+
−
          </td></tr></table>
+
  
 +
              </div>
 +
            </div>
 +
          </div>
 +
      </div>
 +
  <div class="visualClear"></div>
 +
  <br /><br /><br /><br /><br /><br /><br /><br />
 +
</html>
  
−
</div>
+
{{BGU_Israel/footer}}
−
</div>
+
−
<p>
+
−
 
+
−
 
+
−
 
+
−
<div id="social-footer">
+
−
<a id="gotop" href="#"></a>
+
−
 
+
−
 
+
−
 
+
−
 
+
−
<div id="follow">
+
−
  <h2>Follow us:</h2>
+
−
  <div>
+
−
    <a id="adress" href="http://igembgu2015hp.wix.com/boomerang" target="blank"></a>
+
−
    <a id="mail" href="mailto:igembgu2015@gmail.com "></a>
+
−
    <a id="facebook" href="https://www.facebook.com/iGEMBGU" target="blank"></a>
+
−
    <a id="twitter" href="https://twitter.com/BGU_iGEM" target="blank"></a>
+
−
    <a id="youtube" href="http://player.vimeo.com/video/110058399" target="blank"></a>
+
−
  </div>
+
−
</div>
+
−
 
+
−
 
+
−
 
+
−
 
+
−
  <div id="Div2">
+
−
  <h2>Address:</h2>
+
−
  <p> <br />
+
−
  <p> <br />
+
−
 
+
−
</div>
+
−
 
+
−
</div>
+
−
 
+
−
 
+
−
</p>
+
−
<!--
+
−
NewPP limit report
+
−
Preprocessor node count: 74/1000000
+
−
Post-expand include size: 133/2097152 bytes
+
−
Template argument size: 0/2097152 bytes
+
−
Expensive parser function count: 0/100
+
−
-->
+
−
 
+
−
<!-- Saved in parser cache with key 2013_igem_org:pcache:idhash:107-0!1!0!!en!2!edit=0 and timestamp 20150808061127 -->
+
−
<div class="printfooter">
+
−
Retrieved from "<a href="https://2015.igem.org/Team:BGU_Israel">https://2015.igem.org/Team:BGU_Israel</a>"</div>
+
−
<div id="catlinks"><div id='Div1' class='catlinks catlinks-allhidden'></div></div> <!-- end content -->
+
−
<div class="visualClear"></div>
+
−
</div>
+
−
    </div>
+
−
<!-- PAGE FOOTER -- ITEMS FROM COLUMN ! HAVE BEEN MOVED HERE  -- RDR  -->
+
−
<div class="visualClear"></div>
+
−
    <div id='footer-box' class='noprint'>
+
−
        <div id="footer">
+
−
                  <div id="f-copyrightico"><a href="http://creativecommons.org/licenses/by/3.0/"><img src="http://i.creativecommons.org/l/by/3.0/88x31.png" alt="Attribution 3.0 Unported" width="88" height="31" /></a></div>    
+
−
            <ul id="f-list">
+
−
+
−
 
+
−
  <!-- Recentchanges is not handles well DEBUG -->
+
−
+
−
 
+
−
            </ul>
+
−
        </div> <!-- close footer -->
+
−
       
+
−
    </div> <!-- close footer-box -->
+
−
+
−
<script>    if (window.runOnloadHook) runOnloadHook();</script>
+
−
<!-- Served in 0.149 secs. --></div></body>
+
−
 
+
−
</html>
+

Latest revision as of 16:02, 18 September 2015

Team:BGU Israel
Achievements
Project description
Design
Results
Practices and Polices

The Boomerang system: synthetic machine for cancer therapy

Despite recent treatment advancements, cancer is still a major cause of mortality worldwide. One of the fundamental problems preventing the development of effective therapy is the difficulty to target cancer cells exclusively.
In Boomerang, we're engineering a genetic device based on a simple concept of AND logic gate: the activation of our CRISPR/Cas9-based system is dependent on the existence of two cancer-specific promoters that control the expression of Cas9 and gRNA, and the combination of these two will occur only in cancer cells. CRISPR/Cas9 system allows several applications of Boomerang: 1) disruption of genes essential for cancer survival; and 2) activation of suicide genes, or color proteins for cancer cell detection (e.g., for complete surgical removal).
Our system can be potentially designed according to unique characteristics of a patient's tumor, paving the way to personalized medicine. We hope that our strategy will change the approach to cancer treatments.