Difference between revisions of "Team:Dundee/Modeling"
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<div class="row"><!--set class as defined in the style.css file.--> | <div class="row"><!--set class as defined in the style.css file.--> | ||
| − | <h2><b>Introduction</b></h2><!--Set Introduction as a heading for the section.--><br><!--Adds a line break--> <p><!--The p tag starts a new paragraph.-->In our project three approaches were taken within the dry lab; data analysis using principal component analysis (PCA), | + | <h2><b>Introduction</b></h2><!--Set Introduction as a heading for the section.--><br><!--Adds a line break--> <p><!--The p tag starts a new paragraph.-->In our project three approaches were taken within the dry lab; data analysis using principal component analysis (PCA), modelling using ordinary differential equations (ODEs) and practical physics experiments. Mathematical modelling can be used within synthetic biology to reduce complex biological systems to their key components, allowing for a quantitative understanding of the reactions occurring. Models can then be considered in the lab to allow for optimisation of the techniques to produce the best end result. ODEs were used to model the change in concentration of substances over time, this was implemented within all aspects of the project; the BioSpray, fingerprint ageing and chromate detection.</p><!--End the paragraph.--> |
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| − | <p> PCA is a statistical procedure whereby a dataset with many dimensions is simplified to its principal components in order to visualise hidden correlations. PCA was used to analyse the composition of fingerprints for the fingerprint | + | <p> PCA is a statistical procedure whereby a dataset with many dimensions is simplified to its principal components in order to visualise hidden correlations. PCA was used to analyse the composition of fingerprints for the fingerprint ageing. Physics experiments were used to investigate the incisions on bones by stainless steel knives to complement the chromium biosensor part of the toolkit. </p> |
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<p> The development of software, such as MATLAB, has allowed for greater use of mathematical models across the whole of synthetic biology. MATLAB was used in all aspects of the dry lab work, all code used can be found in our appendix via links at the bottom of each section. Click on the buttons below to find out more about each section described.</p> | <p> The development of software, such as MATLAB, has allowed for greater use of mathematical models across the whole of synthetic biology. MATLAB was used in all aspects of the dry lab work, all code used can be found in our appendix via links at the bottom of each section. Click on the buttons below to find out more about each section described.</p> | ||
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<a href="https://2015.igem.org/Team:Dundee/Modeling/Biospray"> <span class="glyphicon glyphicon-tint" type="button"></span></a> <!--This button contains a link to the BioSpray models page.--> | <a href="https://2015.igem.org/Team:Dundee/Modeling/Biospray"> <span class="glyphicon glyphicon-tint" type="button"></span></a> <!--This button contains a link to the BioSpray models page.--> | ||
<h3>BioSpray</h3> | <h3>BioSpray</h3> | ||
| − | <p class="about-content">Find out more about the | + | <p class="about-content">Find out more about the modelling for each of the components of the BioSpray.</p><!--This is the text displayed underneath the button.--> |
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<div class="col-lg-4"> | <div class="col-lg-4"> | ||
<a href="https://2015.igem.org/Team:Dundee/Modeling/Fingerprints"><span class="glyphicon glyphicon-hand-down" type="button"></span></a><!--This button contains a link to the Fingerprints models page.--> | <a href="https://2015.igem.org/Team:Dundee/Modeling/Fingerprints"><span class="glyphicon glyphicon-hand-down" type="button"></span></a><!--This button contains a link to the Fingerprints models page.--> | ||
| − | <h3>Fingerprint | + | <h3>Fingerprint Ageing</h3> |
| − | <p class="about-content">Find out more about principal component analysis (PCA) and | + | <p class="about-content">Find out more about principal component analysis (PCA) and modelling of fingerprint ageing.</p><!--This is the text displayed underneath the button.--> |
</div> | </div> | ||
<div class="col-lg-4"> | <div class="col-lg-4"> | ||
<a href="https://2015.igem.org/Team:Dundee/Modeling/Chromate"><span class="glyphicon glyphicon-pushpin" type="button"></span></a> <!--This button contains a link to the Chromate models page.--> | <a href="https://2015.igem.org/Team:Dundee/Modeling/Chromate"><span class="glyphicon glyphicon-pushpin" type="button"></span></a> <!--This button contains a link to the Chromate models page.--> | ||
<h3>Chromate Sensor</h3> | <h3>Chromate Sensor</h3> | ||
| − | <p class="about-content">Find out more about | + | <p class="about-content">Find out more about modelling of chromate and bone incision experiments.</p><!--This is the text displayed underneath the button.--> |
</div> | </div> | ||
Revision as of 16:12, 7 September 2015
Dry Lab
Introduction
Introduction
In our project three approaches were taken within the dry lab; data analysis using principal component analysis (PCA), modelling using ordinary differential equations (ODEs) and practical physics experiments. Mathematical modelling can be used within synthetic biology to reduce complex biological systems to their key components, allowing for a quantitative understanding of the reactions occurring. Models can then be considered in the lab to allow for optimisation of the techniques to produce the best end result. ODEs were used to model the change in concentration of substances over time, this was implemented within all aspects of the project; the BioSpray, fingerprint ageing and chromate detection.
PCA is a statistical procedure whereby a dataset with many dimensions is simplified to its principal components in order to visualise hidden correlations. PCA was used to analyse the composition of fingerprints for the fingerprint ageing. Physics experiments were used to investigate the incisions on bones by stainless steel knives to complement the chromium biosensor part of the toolkit.
The development of software, such as MATLAB, has allowed for greater use of mathematical models across the whole of synthetic biology. MATLAB was used in all aspects of the dry lab work, all code used can be found in our appendix via links at the bottom of each section. Click on the buttons below to find out more about each section described.
