Difference between revisions of "Team:Dundee/Modelling"

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<b>Modelling-BioSpray: Haptoglobin and Hemoglobin binding</b>
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<b>Introduction</b>
 
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<b>Objective</b>
 
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<p>The aim of a model describing the binding between haptoglobin and haemoglobin is to find the optimum concentration and binding rates that we require for visual detection of haemoglobin in the sample from the crime scene. The more complex formed the more likely it will be that the haemoglobin will be visually detected using the biospray.</p>
 
  
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<b>Model Formation</b>
 
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<p>Haemoglobin is a tetramer, with two \(\alpha\) chains and two \(\beta\) chains. Haptoglobin binds to haemoglobin in two stages. Firstly the haptoglobin binds to the \(\alpha\) chains of the haemeoglobin only. This first reaction is reversible and the complex can dissociate. The haptoglobin then binds to the \(\beta\) chains of the haemoglobin to form an extremely strong complex. This reaction is not reversible. These reactions can be described by the scheme:
 
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Revision as of 09:47, 31 July 2015

DRY LAB

Introduction

BioSpray

The models for the BioSpray focus on each of the components of the BioSpray binding with their targets in the sample.

Fingerprint Aging

Principle component analysis was used to find the most likely composites to be found in the fingerprint. A second model was used to describe the binding between the target composites and the molecules in our device

Chromium Detector

A model of the interactions occuring over time was created. Bone incision experiments were done to complement this.

Introduction