Difference between revisions of "Team:Stanford-Brown/Projects"
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| − | <p class="lead">The BioBricks that we submitted to the registry . Click to see more.</p> | + | <p class="lead">The BioBricks that we submitted to the registry are related to plastic production, cellulose binding, sporulation markers, and pigment production. Click to see more.</p> |
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| − | <h2 class="featurette-heading">How? <span class="small"> with heat, evaporation, and materials that could be produced in space.</span></h2> | + | <h2 class="featurette-heading">How does it work? <span class="small"> with heat, evaporation, and materials that could be produced in space.</span></h2> |
| − | <p class="lead">Bacteria can produce thermoplastics and cellulose | + | <p class="lead">Bacteria can be engineered to produce thermoplastics, and some species naturally produce cellulose. These materials can be folded with heat and evaporation, respectively. Selectively heating certain parts of a thermoplastic sheet causes the polymers in only that area to contract, causing a macro-scale fold of the sheet. This selective heating can be done by coloring parts of the sheet darker, so they absorb heat faster. As for the evaporation method, bacterial spores expand and contract when in the presence of different levels of relative humidity. Attaching many spores to a long cellulose sheet can cause it to contract, and placing many of these sheets in parallel gives them the ability to move a large amount of weight as the water from the spores evaporates and they all contract in unison.</p> |
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| − | <h2 class="featurette-heading">Polystyrene <span class="small">Engineering E. coli to produce polystyrene</span></h2> | + | <h2 class="featurette-heading">Polystyrene <span class="small">Engineering <i>E. coli</i> to produce polystyrene</span></h2> |
| − | <p class="lead"> | + | <p class="lead">Polystyrene is widely-used thermoplastic that is resistant to photolysis. Our team worked on creating the first BioBricks for producing polystyrene <i>in vivo</i>. We believe that the properties of this plastic make it attractive for manufacturing objects on long-term missions to other planets. </p> |
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Revision as of 07:05, 13 September 2015
Projects Overview for manufacturing in space
Our Vision to create biOrigami: self-folding, biological origami for space missions
Space exploration lies at the inquisitive core of human nature, yet high costs hinder the advancement of this frontier. We are harnessing the replicative properties of biology to create biOrigami—biological, self-folding origami—to reduce the mass, volume, and assembly time of materials needed for space missions. biOrigami consists of two main components: manufacturing substrates biologically and bioengineering folding mechanisms. For substrates, we are developing new BioBricks to synthesize two thermoplastics: polystyrene and polyhydroxyalkanoates. For folding mechanisms, we are using heat-induced contraction of thermoplastics and the contractile properties of bacterial spores. After consulting with experts, we believe that biOrigami could be incorporated into rovers, solar sails, and more. In addition to biOrigami, we are creating a novel method to efficiently transform bacteria by using the CRISPR/Cas9 system, benefitting the broader synthetic biology community. Our project integrates and improves manufacturing processes for space exploration on both the micro and macro levels.
Our BioBricks
The BioBricks that we submitted to the registry are related to plastic production, cellulose binding, sporulation markers, and pigment production. Click to see more.
How does it work? with heat, evaporation, and materials that could be produced in space.
Bacteria can be engineered to produce thermoplastics, and some species naturally produce cellulose. These materials can be folded with heat and evaporation, respectively. Selectively heating certain parts of a thermoplastic sheet causes the polymers in only that area to contract, causing a macro-scale fold of the sheet. This selective heating can be done by coloring parts of the sheet darker, so they absorb heat faster. As for the evaporation method, bacterial spores expand and contract when in the presence of different levels of relative humidity. Attaching many spores to a long cellulose sheet can cause it to contract, and placing many of these sheets in parallel gives them the ability to move a large amount of weight as the water from the spores evaporates and they all contract in unison.
Polystyrene Engineering E. coli to produce polystyrene
Polystyrene is widely-used thermoplastic that is resistant to photolysis. Our team worked on creating the first BioBricks for producing polystyrene in vivo. We believe that the properties of this plastic make it attractive for manufacturing objects on long-term missions to other planets.
Polyhydroxyalkanoates Optimizing the production of biological PHA
Donec ullamcorper nulla non metus auctor fringilla. Vestibulum id ligula porta felis euismod semper. Praesent commodo cursus magna, vel scelerisque nisl consectetur. Fusce dapibus, tellus ac cursus commodo.
C.A.S.H. Cellulose Associated Spore HYDRAS, or a biological contractile mechanism
Based on work done by Chen et al. at Columbia university, we sought to employ the contractile properties of bacterial spores to use as a contractile mechanism for biOrigami.
CRATER Crisper Assisted Transformation Efficient Reaction
Donec ullamcorper nulla non metus auctor fringilla. Vestibulum id ligula porta felis euismod semper. Praesent commodo cursus magna, vel scelerisque nisl consectetur. Fusce dapibus, tellus ac cursus commodo.