Difference between revisions of "Team:Freiburg/Project/Overview"
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− | <h1> | + | <h1>DNA Engineering</h1> |
− | <p> | + | <p>Genetic fusion of different antigens and tags is a really basic requirement of our project. To enable many people to work on our DNA constructs in parallel we designed a cloning strategy easy to follow and additionally easy to expand for further needs. |
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+ | Read more about how we combined different cloning methods to reduce our efforts in <a href="https://2015.igem.org/Team:Freiburg/Methods/Cloning" class="wikilink1">DNA Engineering.</a> | ||
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Revision as of 22:26, 15 September 2015
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The DiaCHIP - A Versatile Detection System
![DiaCHIP_Sabi](https://static.igem.org/mediawiki/2015/a/af/Freiburg_DiaCHIP_Sabi.png)
Project Motivation
Serological tests are a key element in modern medicine. Especially when it comes to the detection and identification of infectious diseases, performing different blood tests is inevitable. Regardless of a patient having diffuse symptoms or being tested for a defined number of diseases, more than one serological test has to be performed each time. Many tests, many days of waiting and an increasing bill: For some infectious diseases every minute is important to life and not everyone can afford a long series of testing. What if there was a possibility to combine all tests in one single and affordable device?
Detecting Antigen-Antibody Interactions
The DiaCHIP is an innovative tool to screen for a broad range of antibodies present in serum.
Antibodies can be an indicator for an immune response towards an infection or a successful vaccination.
They also play an important role in the diagnosis of autoimmune diseases.
Especially the ability to differentiate between life threatening diseases and mild infections within a short time bears the potential to save lives.
Spotting diseases by detecting correspondent antibodies in a patient's serum is an established method in modern diagnostics. The DiaCHIP makes it possible to screen for multiple specific antibodies at once simply using a drop of blood.
The Concept
The key feature of the DiaCHIP concept is the combination of on-demand protein synthesis and a novel method for label-free detection packed into one device. The idea is to overcome challenges commonly found in protein array production and preservation. In addition, results can be obtained in a time- and cost-efficient manner; with a device simple enough to be rebuilt by future iGEM Teams.