Difference between revisions of "Team:BGU Israel"

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<h2> Welcome to iGEM 2015! </h2>
 
  
<h2> Hello! We are Ben-Gurion university iGEM team</h2>
 
  
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<p><b> We are developing applications for the diagnosis and treatment of cancer.</b></P>
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<p>Despite the huge investment in research and the development of a variety of treatment methods, cancer is still a major cause of death in the world. Today, both surgical and pharmacological treatments against most types of cancer are not accurate enough to identify and treat the disease on a cellular level. On the other hand, novel biological treatments being developed were only found effective for a relatively small number of patients.</P>  
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<p>In cancer, many cellular and molecular processes take place, enabling the tumor to develop and spread in the body. We believe that it is possible to take advantage of the many typical biological mechanisms of cancer cells, by developing a synthetic biology-based system for identifying and treating cancer on a cellular level.</P>
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<p>Together as a team, we developed a modular system which identifies numerous genetic changes in cancer cells and responds by activating a synthetic machine that executes a cell suicide program or enables color-based "tagging" of the cells for tumor detection, ensuring complete surgical removal.</P>
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<p>Our synthetic machinery is based on cancer cell-specific activation of CRIPSR/Cas9  system. The specificity of the system relies on the expression control of CRISPR/Cas9 components by cancer-specific promoters. The execution of the system can lead to the activation of any gene of interest (e.g., toxins, apoptotic proteins – for cell killing; or fluorescent/color proteins –for cell detection), or essential gene knock-out. We hope to achieve a proof-of- concept for our system in human cancer cell lines.</P>
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<p>The novelty of the system relies on its high specificity, achieved by conditional activation and based on a number of genetic changes that take place specifically in cancer cells. Because such changes vary depending on the person or type of tumors, a modular system of such will enable personalized care for each patient.</P>
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<h3> <u> Find us at <u> </h3>
 
<p><a href="https://www.facebook.com/iGEMBGU" target="_blank"><img src="https://upload.wikimedia.org/wikipedia/commons/0/06/Facebook.svg" alt="facebook logo" height="5%" width="5%"/>
 
<a href="https://www.facebook.com/iGEMBGU" target="_blank">iGEM BGU 2015 Facebook page</a></P>
 
<p><a href="https://twitter.com/BGU_iGEM" target="_blank"><img src="https://upload.wikimedia.org/wikipedia/en/9/9f/Twitter_bird_logo_2012.svg" alt="twitter logo" height="4%" width="4%"/><a href="https://twitter.com/BGU_iGEM" target="_blank">iGEM BGU 2015 twitter page</a></p>
 
  
<p><h1><a href="http://igembgu2015hp.wix.com/boomerang" target="_blank">Visit our website</a></h1></P>
 
  
  
  
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<!--
 
<p>Your team has been approved and you are ready to start the iGEM season! </p>
 
  
<h4>Before you start: </h4>
 
<p> Please read the following pages:</p>
 
<ul>
 
<li>  <a href="https://2015.igem.org/Requirements">Requirements page </a> </li>
 
<li> <a href="https://2015.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
 
</ul>
 
  
<div class="highlightBox">
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<link href="http://igembgu.com/wiki/css/TUM13_normalize.css" type="text/css" rel="stylesheet">
<h4> Styling your wiki </h4>
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<link href="http://igembgu.com/wiki/css/UM13_reset.css" type="text/css" rel="stylesheet">
<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>  
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<h1 class="firstHeading">Team:BGU Israel</h1>
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            <li><a id="home" href="https://2015.igem.org/Team:BGU_Israel">Home</a></li>
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                    <li><a href="https://2013.igem.org/Team:BGU_Israel/Team/Members">Members</a></li>
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                    <li><a href="https://2013.igem.org/Team:BGU_Israel/Team/Gallery">Pictures</a></li>
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                    <li><a href="https://2013.igem.org/Team:BGU_Israel/Team/Statistics">Timeline</a></li>
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                    <li><a href="https://2013.igem.org/Team:BGU_Israel/Team/Judging">Judging</a></li>
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            <li>Project
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                                <li><a id="A1" href="https://2015.igem.org/Team:BGU_Israel/Description">Description</a></li>
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                              <li> <a href="https://2015.igem.org/Team:BGU_Israel/Experiments">Experiments &amp; Protocols</a>  </li>
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                                <li><a href="https://2015.igem.org/Team:BGU_IsraelResults">Results</></a>  </li>
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                                <li><a href="https://2015.igem.org/Team:BGU_Israel/Design">Design</a></li>
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                            </ul>
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            <li>Parts
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            <ul>
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<li><a href="https://2015.igem.org/Team:BGU_Israel/Parts">Team Parts</a></li>
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<li><a href="https://2015.igem.org/Team:BGU_Israel/Basic_Part">Basic Parts</a>  </li>
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<li><a href="https://2015.igem.org/Team:BGU_Israel/Composite_Part">Composite Parts</a></li>
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<li><a href="https://2015.igem.org/Team:BGU_Israel/Part_Collection">Part Collection</a> </li>
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</li>
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<li><a id="A3" href="https://2015.igem.org/Team:BGU_Israel/Notebook">Notebook</a></li>
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            <li> MORE
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                <ul>
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                    <li><a href="https://2015.igem.org/Team:BGU_Israel/Attributions">Attributions</a></li>
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                  <li>  <a href="https://2015.igem.org/Team:BGU_Israel/Collaborations">Collaborations</a></li>
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                  <li> <a href="https://2015.igem.org/Team:BGU_Israel/Practices">Human practices</a></li>
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                  <li> <a href="https://2015.igem.org/Team:BGU_Israel/Safety">Safety</a></li>
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                  <li> <a href="https://2015.igem.org/Team:BGU_Israel/Modeling">Modeling</a></li>
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                  <!-- <li> <a href="https://2015.igem.org/Team:BGU_Israel/Measurement">MEASUREMENT</a></li>
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                  <li> <a href="https://2015.igem.org/Team:BGU_Israel/Entrepreneurship">Entrepreneurship</a></li>
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                </ul>
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            </li>
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<h4> Editing your wiki </h4>
 
<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
 
<p> <a href="https://2015.igem.org/wiki/index.php?title=Team:BGU_Israel&action=edit"> Click here to edit this page! </a></p>
 
<p>See tips on how to edit your wiki on the <a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation</a> page.</p>
 
  
  
  
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                    <td style="border-style: hidden;"><a href="https://2015.igem.org/Team:BGU_Israel/Entrepreneurship" class="rotate"><img src="https://static.igem.org/mediawiki/2015/b/b9/BGU_home_icon_briefcase.png" alt=""></a></td>
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                </tr>
 +
                <tr style="border-style: hidden;">
 +
                    <td style="text-align: left; border-style: hidden;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Entrepreneurship</td>
 +
                    <td style="text-align: left; border-style: hidden;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Safety</td>
 +
                    <td style="text-align: left; border-style: hidden;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Judging</td>
 +
                    <td style="text-align: left; border-style: hidden;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Photos</td>
 +
                    <td style="text-align: left; border-style: hidden;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Extra</td>
 +
                </tr>
  
<h4>Templates </h4>
+
            </table>
<p> This year we have created templates for teams to use freely. More information on how to use and edit the templates can be found on the
+
           
<a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation </a> page.</p>  
+
            <!-- <a href="https://2013.igem.org/Team:TU-Munich/Results/Economics" class="rotate"><img src="https://static.igem.org/mediawiki/2015/b/b9/BGU_home_icon_briefcase.png" alt=""></a>
 +
            <a class="button application" href="https://2013.igem.org/Team:TU-Munich/Results/Implementation">Application</a>
 +
            <a class="button autoannotator" href="https://2013.igem.org/Team:TU-Munich/Results/AutoAnnotator">AutoAnnotator</a>
 +
         
 +
            <a class="button physco" href="https://2013.igem.org/Team:TU-Munich/Project/Physcomitrella">Physco</a>
 +
            <a class="button safety" href="https://2013.igem.org/Team:TU-Munich/Project/Safety">Safety</a>
 +
            <a class="button judging" href="https://2013.igem.org/Team:TU-Munich/Team/Judging">Judging</a> -->
 +
        </div>
  
 +
<h2> <span class="mw-headline" id="PhyscoFilter_.E2.80.93_Clean_different."> Cancer &ndash; what is the problem? </span></h2>
 +
        <p>Despite the huge investment in research and the development of a variety of treatment methods, cancer is still a major cause of death in the world.
 +
            <br /> Today, both surgical and pharmacological treatments against most types of cancer are not accurate enough to identify and treat the disease on a cellular level.
 +
            On the other hand, novel biological treatments being developed were only found effective for a relatively small number of patients.
 +
            <br />In cancer, many cellular and molecular processes take place, enabling the tumor to develop and spread in the body.
 +
            <br />We believe that it is possible to take advantage of the many typical biological mechanisms of cancer cells, by developing a synthetic biology-based system for identifying and treating cancer on a cellular level.
 +
            Together as a team, we developed a modular system which identifies numerous genetic changes in cancer cells and responds by activating a synthetic machine that executes a cell suicide program or enables color-based "tagging" of the cells for tumor detection, ensuring complete surgical removal.</p>
 +
       
 +
       
 +
       
 +
            <!-- movie -->
 +
        <right><iframe style="box-shadow: 1px 1px 2px rgba(0, 0, 0, 0.2);padding: 5px;margin: 5px;background-color: white;" src="http://player.vimeo.com/video/110058399" width="900" height="510" frameborder="0" webkitAllowFullScreen mozallowfullscreen allowFullScreen></iframe></right>
 +
</p>
  
<h4>Tips</h4>
 
<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
 
<ul>
 
<li>State your accomplishments! Tell people what you have achieved from the start. </li>
 
<li>Be clear about what you are doing and how you plan to do this.</li>
 
<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
 
<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
 
<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
 
<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2015.igem.org/Calendar_of_Events">iGEM 2015 calendar</a> </li>
 
<li>Have lots of fun! </li>
 
</ul>
 
  
  
<h4>Inspiration</h4>
 
<p> You can also view other team wikis for inspiration! Here are some examples:</p>
 
<ul>
 
<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
 
<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
 
<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
 
<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
 
<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
 
<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
 
</ul>
 
  
<h4> Uploading pictures and files </h4>
+
<!-- achivments -->
<p> You can upload your pictures and files to the iGEM 2015 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
+
When you upload, set the "Destination Filename" to <code>Team:YourOfficialTeamName/NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
+
  
<a href="https://2015.igem.org/Special:Upload">CLICK HERE TO UPLOAD FILES</a>
+
<h2> <span class="mw-headline" id="Achievements"> Achievements </span></h2>
 +
<p><div class="thumb tright" id="blubberkolben">
 +
    <div class="thumbinner" style="width:400px;">
 +
        <a href="/File:TUM13_blubbern-stop.gif" class="image">
 +
            <img alt="" src="https://static.igem.org/mediawiki/2013/a/ab/TUM13_blubbern-stop.gif" width="400" class="thumbimage" />
 +
        </a>
 +
        <div class="thumbcaption">
 +
            <div class="magnify">
 +
                <a href="/File:TUM13_Physco-lifecycle.png" class="internal" title="Enlarge">
 +
                    <img src="/wiki/skins/common/images/magnify-clip.png" width="15" height="11" alt="" />
 +
                </a>
 +
            </div>
 +
        Hover over the picture!<br />Then you can actually <b>HEAR</b> the sound in our laboratory.
 +
        </div>
 +
    </div>
 +
</div>
 +
</p>
 +
<div class="achievements">
 +
<h4> <span class="mw-headline" id="European_Jamboree_results:"> European Jamboree <a href="https://igem.org/Results?year=2013&amp;region=All&amp;division=igem" class="external text" rel="nofollow">results</a>: </span></h4>
 +
<ul><li> Gold medal
 +
</li><li> Best Wiki
 +
</li><li> European First Runner Up
 +
</li></ul>
 +
<h4> <span class="mw-headline" id="World_Jamboree_results:"> World Jamboree <a href="https://igem.org/Results?year=2013&amp;region=All&amp;division=igem" class="external text" rel="nofollow">results</a>: </span></h4>
 +
<ul><li> Best Environment Project
 +
</li><li> World First Runner Up
 +
</li></ul>
 +
<h4> <span class="mw-headline" id="Business_plan_competitions_after_iGEM:"> Business plan competitions after iGEM: </span></h4>
 +
<ul><li> 1<sup>st</sup> place at the <a href="http://www.tum.de/die-tum/aktuelles/pressemitteilungen/kurz/article/31350/" class="external text" rel="nofollow">TUM IdeAward</a>
 +
</li><li> 2<sup>nd</sup> place at the <a href="http://www.presseportal.de/print/2731699-projekt-zum-internet-der-dinge-gewinnt-hochschulwettbewerb-der.html" class="external text" rel="nofollow">Be.Project Competition</a>
 +
</li><li> 3<sup>rd</sup> place in the second round of the <a href="http://www.tum.de/wirtschaft/entrepreneurship/entrepreneurship-news/artikel/article/31515/" class="external text" rel="nofollow">Munich Business Plan Competition</a>
 +
</li></ul>
 +
</div>
  
 +
<!-- SPONSERS -->
 +
        <!--
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<h2> <span class="mw-headline" id="Sponsors"> Sponsors </span></h2>
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<p>
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<a class="sponsor" href="http://www.tum.de/"><img src="https://static.igem.org/mediawiki/2013/9/97/Logo_TU-Muenchen_01.png" width="190px"></a>
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<a class="sponsor" href="http://wzw.tum.de/"><img src="https://static.igem.org/mediawiki/2013/a/ac/Wzwlogo2.png" width="210px"></a>
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<a class="sponsor" href="http://www.daad.de/de/index.html"><img src="https://static.igem.org/mediawiki/2013/f/f7/TUM13_DAAD.jpg" width="120px"></a>
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<a class="sponsor" href="http://www.geneious.com/"><img src="https://static.igem.org/mediawiki/2012/8/82/TUM_Geneious.png" width="190px"></a>
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<a class="sponsor" href="http://www.mathworks.de/"><img src="https://static.igem.org/mediawiki/2013/0/0c/TUM13_MathWorks.png" width="200px"></a>
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<a class="sponsor" href="http://www.ika.com/"><img src="https://static.igem.org/mediawiki/2013/9/9d/TUM13_IKA.png" width="105px"></a>
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<a class="sponsor" href="http://www.neb.com/"><img src="https://static.igem.org/mediawiki/2013/5/50/TUM13_Sponsor_NEB.jpg" width="155px"></a>
 +
<a class="sponsor" href="http://www.promega.de/"><img src="https://static.igem.org/mediawiki/2013/f/f0/Promega-300.jpg" width="175px"></a>
 +
<a class="sponsor" href="http://www.qiagen.com/"><img src="https://static.igem.org/mediawiki/2013/6/60/TUM13_Sponsor_Qiagen.png" width="100px"></a>
 +
<a class="sponsor" href="http://www.iba-lifesciences.com/"><img src="https://static.igem.org/mediawiki/2013/9/9c/Iba_logo_claim_r_farbe.jpg" width="180px"></a>
 +
<a class="sponsor" href="http://eu.idtdna.com/site/"><img src="https://static.igem.org/mediawiki/2013/1/13/Bonn_sponsor_idt.jpg" width="180px"></a>
 +
<a class="sponsor" href="http://www.thermoscientific.com"><img src="https://static.igem.org/mediawiki/2013/e/ed/TUM13_Sponsor_logo_Thermo.jpg" width="140px"></a>
 +
<a class="sponsor" href="http://www.erasynbio.eu/"><img src="https://static.igem.org/mediawiki/2013/5/58/Logo_ERASynBio.png" width="180px"></a>
 +
<div class="visualClear"></div>
 +
<a class="sponsor" style="float: none; margin: 10px auto;" href="http://www.roche.com/"><img src="https://static.igem.org/mediawiki/2013/d/d2/TUM13_Roche.jpg" height="80px"></a>
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        <!-- Map of entering the website from around the world -->
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    <center style="margin-top: 10px;">
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        <div id="clustrmaps-widget"></div><script type="text/javascript">var _clustrmaps = { 'url': 'https://2015.igem.org/Team:BGU_Israel', 'user': 1176746, 'server': '3', 'id': 'clustrmaps-widget', 'version': 1, 'date': '2015-08-19', 'lang': 'en', 'corners': 'square' }; (function () { var s = document.createElement('script'); s.type = 'text/javascript'; s.async = true; s.src = 'http://www3.clustrmaps.com/counter/map.js'; var x = document.getElementsByTagName('script')[0]; x.parentNode.insertBefore(s, x); })();</script><noscript><a href="http://www3.clustrmaps.com/user/9bc11f4aa"><img src="http://www3.clustrmaps.com/stats/maps-no_clusters/2015.igem.org-Team-BGU_Israel-thumb.jpg" alt="Locations of visitors to this page" /></a></noscript>
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    </center>
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</p>
 +
</div>
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</div>
 +
<p>
 +
 +
 +
 +
<div id="social-footer">
 +
<a id="gotop" href="#"></a>
 +
 +
 +
<div id="follow">
 +
  <h2>Follow us:</h2>
 +
  <div>
 +
    <a id="adress" href="http://igembgu2015hp.wix.com/boomerang" target="blank"></a>
 +
    <a id="mail" href="mailto:igembgu2015@gmail.com "></a>
 +
    <a id="facebook" href="https://www.facebook.com/iGEMBGU" target="blank"></a>
 +
    <a id="twitter" href="https://twitter.com/BGU_iGEM" target="blank"></a>
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    <a id="youtube" href="http://player.vimeo.com/video/110058399" target="blank"></a>
 +
  </div>
 +
</div>
 +
 +
 +
<div id="address">
 +
  <h2>Address:</h2>
 +
  <p>iGEM Team BGU-ISRAEL<br />
 +
  <p>Email: <a id="A4" href="mailto:igembgu2015@gmail.com">igembgu2015@gmail.com</a><br />
 +
    Phone: +972 52 332 2412</p>
 +
</div>
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</div>
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</p>
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Revision as of 16:56, 19 August 2015


Team:BGU Israel - 2015.igem.org

Team:BGU Israel


      Entrepreneurship       Safety       Judging       Photos       Extra

Cancer – what is the problem?

Despite the huge investment in research and the development of a variety of treatment methods, cancer is still a major cause of death in the world.
Today, both surgical and pharmacological treatments against most types of cancer are not accurate enough to identify and treat the disease on a cellular level. On the other hand, novel biological treatments being developed were only found effective for a relatively small number of patients.
In cancer, many cellular and molecular processes take place, enabling the tumor to develop and spread in the body.
We believe that it is possible to take advantage of the many typical biological mechanisms of cancer cells, by developing a synthetic biology-based system for identifying and treating cancer on a cellular level. Together as a team, we developed a modular system which identifies numerous genetic changes in cancer cells and responds by activating a synthetic machine that executes a cell suicide program or enables color-based "tagging" of the cells for tumor detection, ensuring complete surgical removal.

Achievements

Hover over the picture!
Then you can actually HEAR the sound in our laboratory.

European Jamboree results:

  • Gold medal
  • Best Wiki
  • European First Runner Up

World Jamboree results:

  • Best Environment Project
  • World First Runner Up

Business plan competitions after iGEM: