Team:Cornell/drylab

Cornell iGEM

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Overview

fishPHARM’s mechanical engineering work centers around two main principles: 1) the real-world implementation of a peptide treatment for bacterial coldwater disease (BCWD), and 2) the prevention of bacterial coldwater disease outbreaks on fish farms. To address these goals, fishPHARM has developed engineering solutions for the individualized delivery of flavocide, our bioengineered peptide treatment for BCWD, as well as a fish farm tank monitoring system for the constant monitoring of aquaculture conditions.


fishPHARM presents fishBIT, a novel means of delivering time-released flavocide gel to each fish individually. Inspired by fish tags, devices used to track fish in the wild, fishBIT allows fish farmers to target specific fish for flavocide treatment. Farmers can choose to apply the fishBIT system to a few affected fish, or to their whole farms. Each delivery device can store enough flavocide to treat one fish for the prescribed dosing period, as well as be easily re-dosed, making it an effective means of treating multiple and recurring infections. The device operates through passive diffusion of flavocide suspended in a medical hydrogel. FishBIT is safe for the fish, and is constructed using materials which are all approved by the FDA. Testing of the fishBIT system in a hydraulic flow channel has shown that fishBIT can resist normal fish motion and speeds.


FishPHARM presents the Heimdall Monitoring System (HMS). Named after the Norse god of surveillance, the HMS consists of sensor hardware to be installed within aquaculture tanks, as well as a mobile app for the continuous monitoring and collection of temperature, flow rate, dissolved oxygen concentration, and nitrogen concentration. These factors are important in the health of a fish hatchery, and if improperly maintained, will lead to infections and higher mortality rates. Current methods of monitoring these factors are inefficient and not as reactive to changes in conditions. The HMS is still in its development phase. A first prototype of the hardware is in the process of being built, and the mobile app is ready for testing.


Future work will be done at fishPHARM to improve the design and manufacturing of fishBIT for mass production. Additional testing will be conducted as we plan to apply for FDA approval of the device. The HMS will be prototyped extensively to develop a more efficient design, and its mobile app will continue to be streamlined.

Components

Fabrication & Assembly

Testing