Difference between revisions of "Team:KU Leuven/Modeling"

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                                 <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Top">
 
                                 <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Top">
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                                     <h2>Colony level</h2>
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                                     <h2>Colony</h2>
 
                                     <p>
 
                                     <p>
 
                                         Our colony layer model relies on a Keller-Segel type system of partial differential
 
                                         Our colony layer model relies on a Keller-Segel type system of partial differential
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                             <div class="subtext">
 
                                 <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Hybrid">
 
                                 <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Hybrid">
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                                     <h2>Hybrid model</h2>
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                                     <h2>Hybrid</h2>
 
                                     <p>Our hybrid model merges both colony and internal level to define the cell-cell
 
                                     <p>Our hybrid model merges both colony and internal level to define the cell-cell
 
                                     interactions of our pattern forming cells. </p>
 
                                     interactions of our pattern forming cells. </p>
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                             <div class="subtext">
 
                                 <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Internal">
 
                                 <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Internal">
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                                     <h2>Internal model</h2>
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                                     <h2>Internal</h2>
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                                     <p>Our internal model aims to simulate the internal dynamics of every cell with a system of
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                                     <p>Our internal model aims to simulate the internal dynamics of every cell with a system of ordinary differential equations. </p>
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                                    ordinary differential equations. </p>
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                                 </a>
 
                                 </a>
 
                             </div>
 
                             </div>
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                             <div class="subtext">
 
                                 <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Toulouse">
 
                                 <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Toulouse">
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                                     <h2>Toulouse model</h2>
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                                     <h2>FBA (Toulouse)</h2>
 
                                     <p>
 
                                     <p>
 
                                         As a part of our modeling cooperation we exchanged models with the Toulouse
 
                                         As a part of our modeling cooperation we exchanged models with the Toulouse
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                         <div class="subimgm">
 
                         <div class="subimgm">
 
                             <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Top">
 
                             <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Top">
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                                 <b>Colony level</b>
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                                 <b>Colony</b>
 
                                 <img
 
                                 <img
 
                                     src="https://static.igem.org/mediawiki/2015/6/6a/KU_Leuven_Wiki_Button_-_Colony_level2.png"
 
                                     src="https://static.igem.org/mediawiki/2015/6/6a/KU_Leuven_Wiki_Button_-_Colony_level2.png"
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                         <div class="subimgm">
 
                             <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Hybrid">
 
                             <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Hybrid">
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                             <b>Hybrid model</b>
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                             <b>Hybrid</b>
 
                             <img
 
                             <img
 
                                 src="https://static.igem.org/mediawiki/2015/0/02/KU_Leuven_Wiki_Button_-_Hybrid_model2.png"
 
                                 src="https://static.igem.org/mediawiki/2015/0/02/KU_Leuven_Wiki_Button_-_Hybrid_model2.png"
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                             <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Hybrid">
 
                             <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Hybrid">
 
                                 <p>
 
                                 <p>
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                                     Coming soon
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                                     Our hybrid model merges both colony and internal level to define the cell-cell
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                                     <br/>
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                                     interactions of our pattern forming cells.
 
                                 </p>
 
                                 </p>
 
                             </a>
 
                             </a>
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                             <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Internal">
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                             <b>Internal model</b>
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                             <b>Internal</b>
 
                             <img
 
                             <img
 
                                 src="https://static.igem.org/mediawiki/2015/4/47/KU_Leuven_Wiki_Button_-_Internal_model2.png"
 
                                 src="https://static.igem.org/mediawiki/2015/4/47/KU_Leuven_Wiki_Button_-_Internal_model2.png"
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                             <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Internal">
 
                             <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Internal">
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                                 <p>
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                                 <p>Our internal model aims to simulate the internal dynamics of every cell with a system of ordinary differential equations.
−
                                    Coming soon
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−
                                    <br/>
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                                 </p>
 
                                 </p>
 
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                             </a>
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                             <a href="https://2015.igem.org/Team:KU_Leuven/Modeling/Toulouse">
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                             <b>Toulouse model</b>
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                             <b>FBA (Toulouse)</b>
 
                             <img src="https://static.igem.org/mediawiki/2015/b/b1/KU_Leuven_Wiki_Button_Flux2.png"
 
                             <img src="https://static.igem.org/mediawiki/2015/b/b1/KU_Leuven_Wiki_Button_Flux2.png"
 
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Revision as of 15:20, 17 September 2015

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Modeling

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The fascinating properties of pattern creating bacteria may be translated into the language of mathematics. In this subsection we are investigating the equations behind the behaviour of the genetically modified organisms created in the wetlab. We do so using a layered approach. Colony level modeling employs partial differential equations to describe large cell groups which are treated as a continuum. Internal level models describe the interactions that happen within single cells. Finally the hybrid model merges the two approaches into a final description of our pattern forming cells.





Colony

Our colony layer model relies on a Keller-Segel type system of partial differential equations. These equations are simulated using finite differences.

Hybrid

Our hybrid model merges both colony and internal level to define the cell-cell interactions of our pattern forming cells.

Internal

Our internal model aims to simulate the internal dynamics of every cell with a system of ordinary differential equations.

FBA (Toulouse)

As a part of our modeling cooperation we exchanged models with the Toulouse team. This is the flux balance analysis they performed for us.
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Colony

Our colony layer model relies on a Keller-Segel type system of differential equations. These equations are simulated using finite differences.

Hybrid

Our hybrid model merges both colony and internal level to define the cell-cell interactions of our pattern forming cells.

Internal

Our internal model aims to simulate the internal dynamics of every cell with a system of ordinary differential equations.

FBA (Toulouse)

As a part of our modeling cooperation we exchanged models with the Toulouse team. This is the flux balance analysis they performed for us.

Contact

Address: Celestijnenlaan 200G room 00.08 - 3001 Heverlee
Telephone: +32(0)16 32 73 19
Email: igem@chem.kuleuven.be