Team:Paris Bettencourt/Results

Throughout the summer, we have imagined a disruptive product that we believe will be a step forward for solving malnutrition.

We repurposed fermentation for creating nutrionally enhanced food

  • We created an modified strain of E. coli that produces vitamin B2 to high levels, and built a vector for allowing Lactococcus, an endogenous micro-organism of idli, to produce the vitamin as well.
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  • We measured the overproduction of vitamin A by an engineered strain of S. cerevisiae, and showed that this does not significantly impair its growth. We demonstrated that backslopping of engineered strains is possible.
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  • We re-engineered the microbiome of traditional Indian dishes, and proved that an exogenous organism with high vitamin production can be introduced in idli.
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  • We modified the genetic regulation circuits of S. cerevisiae so it improves the rice's iron bioavailability by degrading phytic acid, a chelator of iron.
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  • We proved the safety of our product by proving that no micro-organism survives cooking, bringing new opportunities to the GMO debate.
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We designed a truly sustainable solution

  • We found effective, easily acceptable solutions for manufacturing, distribution and conservation of microbial products.
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  • We designed and constructed a new synthetic biology framework for microbes producing nutrients.
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  • We designed a device to detect vitamin B12 in food that is way cheaper than its analytical chemistry counterparts.
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We identified the needs of the target population and provided feasible solutions

  • We got promising feedback from Indian people, researchers and officials, including the former Director of the Council of Scientific and Industrial Research and founder of IGIB.
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  • We successfully defended our project in front of a citizen review commitee.
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  • We shown that rice is often the only resource people have, so our design will be an effective solution for them, as it can be manufactured with only rice water.
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  • We got a lot of citizen involvement and gathered more than fifty sale promises proving the high acceptance of our product by the community.
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