Difference between revisions of "Team:Paris Bettencourt/Background"

 
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<h1>Background</h1>
 
<h1>Background</h1>
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Malnutrition is a condition resulting from an inappropriate intake of nutrients. It can occur as a result of taking in too few (undernutrition) or too many nutrients (overnutrition).<br>
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Humans are not able to produce all of the compounds they need to function properly using only a source of energy such as glucose. We have to rely on other organisms like plants or bacteria to produce vitamins, to extract minerals from water and from the ground, and to turn glucose and nitrogen into amino acids that are essential to our well being. There is an estimated 850 million of undernourished people in the world, and an additional 1 billion people are malnourished.<br>Along with general weakness and fatigue, the lack of certain micronutrients is responsible for a wide variety of medical and mental health conditions that are very often life-threatening.<br>Malnutrition also weakens the immune system, facilitating infectious outbreaks and worsening the outcome of disease.<br>
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Malnutrition is a lack of vital nutrients. Many vitamins, minerals, and essential amino acids can not be produced by human metabolism and must be obtained from dietary sources for good health. One billion people worldwide do not have an adequate diet and are malnourished, and an additional 850 million people are undernourished. The consequences are weakness, fatigue, blindness, infant mortality, compromised immunity, and many dangerous and debilitating medical and mental health conditions.
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Efforts to fight malnutrition have been shown to be one of the most efficient developmental aids for developing countries.  
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Efforts to fight malnutrition have been shown to be one of the most efficient developmental aids for developing countries. In 2015, the Paris Bettencourt iGEM team will produce genetically engineered microbes to produce and distribute zero-cost vitamin supplements to specific communities that need them.
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<h2>A Tour of the Deficiencies and Deficiencies Related Disorders around the world</h2>
 
<h2>A Tour of the Deficiencies and Deficiencies Related Disorders around the world</h2>
 
<br>
 
<br>
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<h3>Vitamin A deficiency (VAD)</h3>
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<h3>Vitamin A Deficiency</h3>
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<br>is, along with iron, iodine and zinc deficiencies, one of the most prevalent and severe micronutrient deficiencies in the world.
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<br>
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<br>Vitamin A deficiency (VAD) is, along with iron, iodine and zinc deficiencies, one of the most prevalent and severe micronutrient deficiencies in the world.
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People whose diets are mostly based on starchy foods like rice are especially at risk of VAD, as these foods do not contain retinol (vitamin A) or provitamin A (carotenoids).
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People whose diets are mostly based on starchy foods like rice are especially at risk, as these foods do not contain retinol (vitamin A) or provitamin A (carotenoids).
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<br>
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Symptoms of vitamin A deficiency include xerophthalmia (extreme dryness of the eyes), night blindness, retinal degeneration, cancer, impaired immune response, birth defects and death.
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Symptoms of VAD include xerophthalmia (extreme dryness of the eyes), night blindness, retinal degeneration, cancer, impaired immune response, birth defects and death.
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13.8 million children have some degree of vision loss related to vitamin A deficiency.
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<br>
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It is estimated that 250,000,000 preschool children have a vitamin A deficiency. Of those 250 million, 500,000 become blind every year.
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13.8 million children have some degree of vision loss related to VAD.
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It is estimated that 250,000,000 preschool children have a VAD. Of those 250 million, 500,000 become blind every year.
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Half of the children who become blind die within 12 months.
 
Half of the children who become blind die within 12 months.
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<br><i>(Highest prevalence of vitamin A deficiency are reported in regions of Africa and South-East Asia.)</i>
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<br><i>(The highest prevalence of vitamin A deficiencies are reported in regions of Africa and South-East Asia.)</i>
 
<br><br><br><br>
 
<br><br><br><br>
  
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In India an estimated 2 million people die every year because of VAD related diseases. 1.9 million are disabled for the rest of their lifes. The states with the lower incomes are the most affected. <br>
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In India, an estimated 2 million people die every year because of vitamin A deficiency-related diseases. 1.9 million are disabled for the rest of their lives. The states with the lowest incomes are the most affected. <br>
  
 
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<img src="https://static.igem.org/mediawiki/2015/0/05/Igemparisbettencourtmapofirondeficiency2015.png" width='1200px'>
 
<img src="https://static.igem.org/mediawiki/2015/0/05/Igemparisbettencourtmapofirondeficiency2015.png" width='1200px'>
  
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<br><i>WHO estimates of iron deficiency anemia rates in 2002( yellow is least, red is highest.)</i><br>
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<br><i>WHO estimates of iron deficiency anemia rates in 2002 (yellow is lowest, red is highest.)</i><br>
 
<br><br>
 
<br><br>
 
The main cause of iron deficiency is inadequate intake.
 
The main cause of iron deficiency is inadequate intake.
 
Symptoms of iron deficiency include fatigue, dizziness, hair loss, weakness, pica, anemia and thrombocytosis.
 
Symptoms of iron deficiency include fatigue, dizziness, hair loss, weakness, pica, anemia and thrombocytosis.
 
<br>
 
<br>
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A simple way to avoid iron deficiency-related disorders is to eat iron containing food like red meat, poultry and insects.There are also non-heme sources of iron like lentils, beans and tofu, but iron from these sources have reduced bioavailabilities.
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The consumption of foods with high iron content, such as red meat, poultry, and insects can prevent iron deficiency-related disorders. Non-heme iron can be found in vegetables such as lentils, beans, and tofo, but has a reduced bioavailability.
 
<br>
 
<br>
 
<img src="https://static.igem.org/mediawiki/2015/a/a0/Igemparisbettencourthemeiron2015.png" width="200px">
 
<img src="https://static.igem.org/mediawiki/2015/a/a0/Igemparisbettencourthemeiron2015.png" width="200px">
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Riboflavin is a cofactor involved in a lot of enzymatic reactions. It can be found in milk, legumes, yeasts, mushrooms …<br>
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Riboflavin is a cofactor involved in a lot of enzymatic reactions. It can be found in many foods, including meat, legumes, and mushrooms.<br>
 
Yeast extract is known to be especially rich in B2. <br>
 
Yeast extract is known to be especially rich in B2. <br>
 
<br>
 
<br>
 
Ariboflavinosis symptoms are including ulcerations of the mouth, tongue and lips, rashes, inflammation of the eyes, photosensibility. Because of it’s involvment in iron absorbtion, B2 deficiency often results in anemia.<br>
 
Ariboflavinosis symptoms are including ulcerations of the mouth, tongue and lips, rashes, inflammation of the eyes, photosensibility. Because of it’s involvment in iron absorbtion, B2 deficiency often results in anemia.<br>
 
Deficiency during pregnancy can result in heart defects and deformities.<br><br>
 
Deficiency during pregnancy can result in heart defects and deformities.<br><br>
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Because Riboflavin is not stored in the body, it needs to be eaten on a regular basis.<br>
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Because riboflavin is not stored in the body, it needs to be eaten on a regular basis.<br>
 
In rice eating population of Asia, studies are showing that even if the average energy intake is adequate, the average riboflavin consumption was only covering 70% the RDA. This partially explain the spreading of anemia in south-east Asia and in India<br><br>
 
In rice eating population of Asia, studies are showing that even if the average energy intake is adequate, the average riboflavin consumption was only covering 70% the RDA. This partially explain the spreading of anemia in south-east Asia and in India<br><br>
 
<img src="https://static.igem.org/mediawiki/2015/7/7c/Riboflavineillustrationfromwikipediathankwikipedia.png" width="200px">
 
<img src="https://static.igem.org/mediawiki/2015/7/7c/Riboflavineillustrationfromwikipediathankwikipedia.png" width="200px">
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<i>Riboflavine</i>
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<i>Riboflavin</i>
 
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<br><h3>Cobalamin (vitamin B12) Deficiency or Hypocobalaminemia</h3><br>
 
<br><h3>Cobalamin (vitamin B12) Deficiency or Hypocobalaminemia</h3><br>
  
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Vitamin B12 or cobalamin is a complex molecule that can only be produced by bacteria. All animals have to get their B12 from microorganismes by various way. Humans usually get their B12 from meat, fish, eggs and dairy product. Vegetarian and especially vegan populations are at risk of deficiency. <br>
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Vitamin B12 or cobalamin is a complex molecule that can only be produced by bacteria. All animals have to get their B12 from microorganisms in various ways. Humans usually get their B12 from consuming meat, fish, eggs and dairy products. Vegetarian and especially vegan populations are at risk of having a B12 deficiency.
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Because of various cultural and socio-economic factors a majority of indians are following a vegetarian diet. <br><br>
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<br><br>
  
 
B12 is crucial for brain and nervous system development and maintenance. Lack of it can cause severe and irreversible damages to the brain and nervous system. Symptoms are including depression, psychosis, lethargy and extreme weakness.<br><br>
 
B12 is crucial for brain and nervous system development and maintenance. Lack of it can cause severe and irreversible damages to the brain and nervous system. Symptoms are including depression, psychosis, lethargy and extreme weakness.<br><br>
  
  
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In India, studies are showing that an alarming proportion of 75% of people have metabolic signs of b12 deficiency (hyperhomocysteinemia and methylmalonic acidemia). Also 50% of pregnant Indian women have low levels of plasmatic b12 which can lead to birth defects. 80% of preschool children are also deficient.<br><img src="https://static.igem.org/mediawiki/2015/2/2b/Igemparisbettencourt2015jbvcokloakmine.png" width="200px">
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In India, a majority of the population follows a vegetarian diet due to various cultural and socio-economic factors. Studies have shown that 75% of people have metabolic signs of b12 deficiency (hyperhomocysteinemia and methylmalonic acidemia). Additionally, 50% of pregnant Indian women have low levels of plasmatic B12, which can lead to birth defects. 80% of preschool children are also deficient.<br><img src="https://static.igem.org/mediawiki/2015/2/2b/Igemparisbettencourt2015jbvcokloakmine.png" width="200px">
 
<i>Cobalamin</i><br>
 
<i>Cobalamin</i><br>
 
<br><br><br><br>
 
<br><br><br><br>

Latest revision as of 17:18, 13 November 2015

Background

Malnutrition is a lack of vital nutrients. Many vitamins, minerals, and essential amino acids can not be produced by human metabolism and must be obtained from dietary sources for good health. One billion people worldwide do not have an adequate diet and are malnourished, and an additional 850 million people are undernourished. The consequences are weakness, fatigue, blindness, infant mortality, compromised immunity, and many dangerous and debilitating medical and mental health conditions.
Efforts to fight malnutrition have been shown to be one of the most efficient developmental aids for developing countries. In 2015, the Paris Bettencourt iGEM team will produce genetically engineered microbes to produce and distribute zero-cost vitamin supplements to specific communities that need them.

A Tour of the Deficiencies and Deficiencies Related Disorders around the world


Vitamin A Deficiency


Vitamin A deficiency (VAD) is, along with iron, iodine and zinc deficiencies, one of the most prevalent and severe micronutrient deficiencies in the world. People whose diets are mostly based on starchy foods like rice are especially at risk, as these foods do not contain retinol (vitamin A) or provitamin A (carotenoids). Symptoms of vitamin A deficiency include xerophthalmia (extreme dryness of the eyes), night blindness, retinal degeneration, cancer, impaired immune response, birth defects and death. 13.8 million children have some degree of vision loss related to vitamin A deficiency. It is estimated that 250,000,000 preschool children have a vitamin A deficiency. Of those 250 million, 500,000 become blind every year. Half of the children who become blind die within 12 months.






(The highest prevalence of vitamin A deficiencies are reported in regions of Africa and South-East Asia.)



In India, an estimated 2 million people die every year because of vitamin A deficiency-related diseases. 1.9 million are disabled for the rest of their lives. The states with the lowest incomes are the most affected.



Iron Deficiency

Iron deficiency is the most common deficiency in the world.
WHO estimates of iron deficiency anemia rates in 2002 (yellow is lowest, red is highest.)


The main cause of iron deficiency is inadequate intake. Symptoms of iron deficiency include fatigue, dizziness, hair loss, weakness, pica, anemia and thrombocytosis.
The consumption of foods with high iron content, such as red meat, poultry, and insects can prevent iron deficiency-related disorders. Non-heme iron can be found in vegetables such as lentils, beans, and tofo, but has a reduced bioavailability.

Heme Iron
Phytic acid is a saturated cyclic acid which has a strong affinity for important minerals such as calcium, iron and zinc. Bound minerals form an insoluble precipitate that is far less absorbed in the intestines. It is a major issue for people whose diet is mainly based on foods that contains phytic acid. Rice contains phytic acid and is consumed as a staple food in India and in east Asia, worsening the deficiencies status in those countries.

Phytic Acid

Riboflavin deficiency or ariboflavinosis


Riboflavin is a cofactor involved in a lot of enzymatic reactions. It can be found in many foods, including meat, legumes, and mushrooms.
Yeast extract is known to be especially rich in B2.

Ariboflavinosis symptoms are including ulcerations of the mouth, tongue and lips, rashes, inflammation of the eyes, photosensibility. Because of it’s involvment in iron absorbtion, B2 deficiency often results in anemia.
Deficiency during pregnancy can result in heart defects and deformities.

Because riboflavin is not stored in the body, it needs to be eaten on a regular basis.
In rice eating population of Asia, studies are showing that even if the average energy intake is adequate, the average riboflavin consumption was only covering 70% the RDA. This partially explain the spreading of anemia in south-east Asia and in India

Riboflavin

Cobalamin (vitamin B12) Deficiency or Hypocobalaminemia


Vitamin B12 or cobalamin is a complex molecule that can only be produced by bacteria. All animals have to get their B12 from microorganisms in various ways. Humans usually get their B12 from consuming meat, fish, eggs and dairy products. Vegetarian and especially vegan populations are at risk of having a B12 deficiency.

B12 is crucial for brain and nervous system development and maintenance. Lack of it can cause severe and irreversible damages to the brain and nervous system. Symptoms are including depression, psychosis, lethargy and extreme weakness.

In India, a majority of the population follows a vegetarian diet due to various cultural and socio-economic factors. Studies have shown that 75% of people have metabolic signs of b12 deficiency (hyperhomocysteinemia and methylmalonic acidemia). Additionally, 50% of pregnant Indian women have low levels of plasmatic B12, which can lead to birth defects. 80% of preschool children are also deficient.
Cobalamin




Bibliography Potential impact and cost-effectiveness of Golden Rice Alexander J. Stein1 , H.P.S. Sachdev2 & Matin Qaim October 2006
Samuel T.M.a, f · Duggan C.b, d · Thomas T.a · Bosch R.c · Rajendran R.a · Virtanen S.M.e, f · Srinivasan K.a · Kurpad A.V.a
Malnutrition Quantifying the health impact at national and local levels Monika Blössner Mercedes de Onis (WHO)
Levels & Trends in Child Malnutrition UNICEF-WHO-The World Bank Joint Child Malnutrition Estimates