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When a bioprocess is developed in the lab, glucose is a popular choice for a carbon source. Even for industrial processes, sugars in general remain the number one substrate.[1]
While some processes will be adapted to methanol as the carbon source, most existing processes will still rely on sugars as these are well established and laborous to change.
By converting renewable methanol to glycogen, the bacterial equivalent to starch, we will provide a universal carbon source, connecting many existing bioprocesses to a sustainable substrate.
Our approach
To pave the way for an industrial process, we need to modify E. coli to produce high concentrations of glycogen. It has previously been shown that a knockout of one glycogen degradation enzyme leads to the accumulation of glycogen in the cells (Fig. 2)Cite error: Invalid <ref> tag;
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- ↑ Liu S. 2013. Bioprocess Engineering: Kinetics, Sustainability, and Reactor Design.