Team:Heidelberg/Software

iGEM Team Heidelberg 2015

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Software

Until now aptamers could only be created through a laborious in vitro procedure made of successive rounds of selection (SELEX). We read an inspirational paper, in which the authors proposed in their discussion the possibility to create aptamers via an in silico approach (note that they did not implement the software but simply wrote down some suggestions as how it could be done) Tseng2011. We therefore got excited at the idea of implementing such software. We created the software (open source) and called it MAWS. We could experimentally prove that the software can design functional aptamers. Moreover, we created a second software (JAWS) to in silico ligate in the most optimal way an aptamer with a ribozyme or DNAzyme. Also the results coming from this software were amply validated with experiments. Read more about MAWS Read more about JAWS