Team:UCSF/Project Sub
DESCRIPTION
We are building a synthetic model in S. cerevisiae to understand communication's role in biological decision-making. Our model consists of four main parts: Basic Circuit, Positive Feedback, Signal Degradation, and Clustering. Using the model, we hope to be able to cause a population divergence with an outside stimulus.
To learn more about our synthetic model, click the button below.
MODELING
Our project this year is centered around the emergence of distinct community phenotypes when individuals in a population are allowed to communicate. Focusing on the community phenotype of bimodal activation, our model aims to mathematically estimate distinct states of multiple cells in the population in different immediate extracellular environments.
For more information on our modeling, click the button below.
RESULTS
Our goal for our circuit is to elicit a divergent community response from two genetically similar cells by varying different communication parameters. To measure distinct community responses in our circuit, we will look at INDIVIDUAL (GFP) response versus COMMUNITY (RFP) response.
To learn more about our experiments and results, click the button below.
PARTS
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